Transcontinental spread of multidrug-resistant Mycobacterium bovis

被引:36
|
作者
Long, R
Nobert, E
Chomyc, S
van Embden, J
McNamee, C
Duran, RR
Talbot, J
Fanning, A
机构
[1] Univ Alberta, Dept Med, Edmonton, AB, Canada
[2] Univ Alberta, Dept Med Microbiol, Edmonton, AB, Canada
[3] Univ Alberta, Dept Surg, Edmonton, AB, Canada
[4] Natl Inst Publ Hlth & Environm Protect, Dept Bacteriol, NL-3720 BA Bilthoven, Netherlands
[5] Inst Carlos 3, Minist Sanidad & Consumo, Madrid, Spain
关键词
D O I
10.1164/ajrccm.159.6.9809076
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Globally, the proportion of all cases of tuberculosis (TB) caused by drug-resistant strains is increasing. We report the case of a Canadian citizen who acquired a highly drug-resistant strain of Mycobacterium bovis while visiting a relative with AIDS-related tuberculosis in Spain. The origin of the strain was traced using spoligotyping, a polymerase chain reaction (PCR)-based fingerprint technology, and the European DNA database. The level of primary drug resistance-all five first-line drugs and 19 of 21 second-line drugs-in this case was unprecedented in Canada. Isolation of this strain from a Canadian citizen represents the first report of its appearance in this hemisphere. The infection was contained and combined medical-surgical treatment delivered.
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页码:2014 / 2017
页数:4
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