Regenerative Role of Stem Cell-Derived Extracellular Vesicles in Acute Kidney Injury

被引：4
|
作者：
Medica, Davide [1 ,2 ]
Dellepiane, Sergio [3 ]
Cantaluppi, Vincenzo [1 ,2 ]
机构：
[1] Univ Piemonte Orientale UPO, Dept Translat Med, Nephrol & Kidney Transplantat Unit, Novara, Italy
[2] Univ Piemonte Orientale UPO, Ctr Autoimmune & Allerg Dis CAAD, Novara, Italy
[3] Icahn Sch Med Mt Sinai, New York, NY 10029 USA
来源：
NEPHRON | 2020年 / 144卷 / 12期
关键词：
Acute renal injury; Extracellular vesicle; Stem cell; ENDOTHELIAL PROGENITOR CELLS; RECOVERY; AKI; PROTECT; THERAPY;
D O I：
10.1159/000511347
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Acute kidney injury (AKI) is a frequent complication of hospital admission and worsens short- and long-term patients' prognosis. Currently, AKI treatment remains supportive and no therapy has proven significant benefit in clinical trials. Stem cells (SCs) are a promising therapeutic option, but their translation to the clinical setting is limited by the risk of rejection or aberrant differentiation. Numerous studies have shown how SC effects are mediated by paracrine factors such as extracellular vesicles (EVs). In this review, we describe the preclinical evidence about EV efficacy in acute tubular and glomerular injury and the recently generated clinical data.
引用
收藏
页码：638 / 643
页数：6
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