The pharmacokinetics of nevirapine when given with isoniazid in South African HIV-infected individuals

被引：12
|
作者：
Decloedt, E. H. [1 ]
Mwansa-Kambafwile, J. [2 ]
van der Walt, J-S. [1 ]
McIlleron, H. [1 ]
Denti, P. [1 ]
Smith, P. [1 ]
Wiesner, L. [1 ]
Rangaka, M. [2 ]
Wilkinson, R. J. [2 ,3 ,4 ]
Maartens, G. [1 ]
机构：
[1] Univ Cape Town, Dept Med, Groote Schuur Hosp, Div Clin Pharmacol, ZA-7925 Cape Town, South Africa
[2] Univ Cape Town, Inst Infect Dis & Mol Med, Clin Infect Dis Res Initiat, ZA-7925 Cape Town, South Africa
[3] Univ London Imperial Coll Sci Technol & Med, Div Med, London, England
[4] Natl Inst Med Res, MRC, London NW7 1AA, England
来源：
INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE | 2013年 / 17卷 / 03期
基金：
英国惠康基金; 英国医学研究理事会; 美国国家卫生研究院;
关键词：
isoniazid; nevirapine; drug interactions; HIV; TUBERCULOSIS; ADULTS; HEPATITIS; BOTSWANA;
D O I：
10.5588/ijtld.12.0427
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Isoniazid preventive therapy (IPT) is recommended in patients on antiretroviral treatment. Isoniazid (INH) inhibits CYP3A4, which metabolises nevirapine (NVP). Administration of INH may cause higher NVP concentrations and toxicity. We studied the effect of INH on NVP concentrations in 21 patients randomised to either placebo (n = 13) or INH (n = 8) in an ongoing trial of IPT in patients on ART. INH was associated with a 24% increase in median NVP area under the plasma concentration-time curve for the 12 h dosing interval, which was not statistically significant (P = 0.66).
引用
收藏
页码：333 / 335
页数：3
相关论文
共 50 条
  • [1] The pharmacokinetics of lopinavir/ritonavir when given with isoniazid in South African HIV-infected individuals
    Decloedt, E. H.
    van der Walt, J. S.
    McIlleron, H.
    Wiesner, L.
    Maartens, G.
    [J]. INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, 2015, 19 (10) : 1194 - 1196
  • [2] Nevirapine pharmacokinetics in HIV-infected and HIV/HCV-coinfected individuals
    Vogel, Martin
    Bertram, Norbert
    Wasmuth, Jan-Christian
    Wyen, Christoph
    Voigt, Esther
    Schwarze-Zander, Carolynne
    Sudhop, Thomas
    Faetkenheuer, Gerd
    Rockstroh, Juergen K.
    Reichel, Christoph
    [J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2009, 63 (05) : 988 - 991
  • [3] Nevirapine pharmacokinetics in HIV-infected persons receiving rifapentine and isoniazid for TB prevention
    Podany, A. T.
    Leon-Cruz, J.
    Hakim, J.
    Supparatpinyo, K.
    Omoz-Oarhe, A.
    Langat, D.
    Mwelase, N.
    Kanyama, C.
    Gupta, A.
    Benson, C. A.
    Chaisson, R. E.
    Swindells, S.
    Fletcher, C., V
    [J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2021, 76 (03) : 718 - 721
  • [4] Population pharmacokinetics of nevirapine in Thai HIV-infected patients
    Wattanakul, Thanaporn
    Avihingsanon, Anchalee
    Manosuthi, Weerawat
    Punyawudho, Baralee
    [J]. ANTIVIRAL THERAPY, 2014, 19 (07) : 651 - 660
  • [5] Integration of population pharmacokinetics and pharmacogenetics: an aid to optimal nevirapine dose selection in HIV-infected individuals
    Schipani, Alessandro
    Wyen, Christoph
    Mahungu, Tabitha
    Hendra, Heidy
    Egan, Deirdre
    Siccardi, Marco
    Davies, Gerry
    Khoo, Saye
    Faetkenheuer, Gerd
    Youle, Michael
    Rockstroh, Juergen
    Brockmeyer, Norbert H.
    Johnson, Margaret A.
    Owen, Andrew
    Back, David J.
    [J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2011, 66 (06) : 1332 - 1339
  • [6] Population pharmacokinetics (PK) of nevirapine (NVP) in HIV-infected adults
    Schipani, A.
    Wakeham, K.
    Ggayi, A.
    Kamali, A.
    Lalloo, D. G.
    Youle, M.
    Johnson, M.
    Khoo, S.
    Dickinson, L.
    Back, D.
    [J]. HIV MEDICINE, 2009, 10 : 51 - 51
  • [7] Nevirapine pharmacokinetics and risk of rash and hepatitis among HIV-infected sub-Saharan African women
    Dong, Betty J.
    Zheng, Yu
    Hughes, Michael D.
    Frymoyer, Adam
    Verotta, Davide
    Lizak, Patricia
    Sawe, Frederick
    Currier, Judith S.
    Lockman, Shahin
    Aweeka, Francesca T.
    [J]. AIDS, 2012, 26 (07) : 833 - 841
  • [8] Immune activation in HIV-infected African individuals
    Rizzardini, G
    Trabattoni, D
    Saresella, M
    Piconi, S
    Lukwiya, M
    Declich, S
    Fabiani, M
    Ferrante, P
    Clerici, M
    [J]. AIDS, 1998, 12 (18) : 2387 - 2396
  • [9] Intracellular and plasma pharmacokinetics of efavirenz in HIV-infected individuals
    Almond, LM
    Hoggard, PG
    Edirisinghe, D
    Khoo, SH
    Back, DJ
    [J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2005, 56 (04) : 738 - 744
  • [10] Pharmacokinetics of isoniazid, rifampicin, pyrazinamide and ethambutol in HIV-infected Indian children
    Mukherjee, A.
    Velpandian, T.
    Singla, M.
    Kanhiya, K.
    Kabra, S. K.
    Lodha, R.
    [J]. INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, 2016, 20 (05) : 666 - 672
12345