Overcoming Multidrug Resistance in Human Cancer Cells by Natural Compounds

被引：62
|
作者：
Nabekura, Tomohiro [1 ]
机构：
[1] Niigata Univ Pharm & Appl Life Sci, Fac Pharmaceut Sci, Akiha Ku, Niigata 9568603, Japan
来源：
TOXINS | 2010年 / 2卷 / 06期
关键词：
P-glycoprotein; ABC transporter; anticancer drug; multidrug resistance; phytochemical; cancer chemoprevention; NF-KAPPA-B; P-GLYCOPROTEIN; PHORBOL ESTER; GREEN TEA; CITRUS AURAPTENE; MOLECULAR TARGETS; GRAPEFRUIT JUICE; TUMOR PROMOTION; CARNOSIC ACID; GROWTH ARREST;
D O I：
10.3390/toxins2061207
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
Multidrug resistance is a phenomenon whereby tumors become resistant to structurally unrelated anticancer drugs. P-glycoprotein belongs to the large ATP-binding cassette (ABC) transporter superfamily of membrane transport proteins. P-glycoprotein mediates resistance to various classes of anticancer drugs including vinblastine, daunorubicin, and paclitaxel, by actively extruding the drugs from the cells. The quest for inhibitors of anticancer drug efflux transporters has uncovered natural compounds, including (-)-epigallocatechin gallate, curcumin, capsaicin, and guggulsterone, as promising candidates. In this review, studies on the effects of natural compounds on P-glycoprotein and anticancer drug efflux transporters are summarized.
引用
收藏
页码：1207 / 1224
页数：18
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