Contribution of CYP24A1 variants in coronary heart disease among the Chinese population

Background Cytochrome P450 (CYPs) participate in the mechanisms of cardiovascular disease. The purpose of this research was to evaluate the contributions ofCYP24A1variants to coronary heart disease (CHD) among the Chinese Han population. Methods This study included 505 CHD cases and 508 controls. Four variants ofCYP24A1(rs2762934, rs1570669, rs6068816 and rs2296241) were chosen and genotyped by the Agena MassARRAY system among the Chinese population. The linkage betweenCYP24A1variants and CHD risk were assessed by logistic regression to compute the odds ratio (OR) and 95% confidence interval (CI). Then, multifactor dimensionality reduction (MDR) was applied to analyze the interactions ofCYP24A1variants. Results The results of this study showed thatCYP24A1rs6068816 significantly enhanced CHD risk in multiple genetic models (allele:P = 0.014; codominant:P = 0.015; dominant:P = 0.043; recessive:P = 0.040; additive:P = 0.013), whereas rs2296241 was likely to protect individuals from CHD (codominant:P = 0.019; recessive:P = 0.013; additive:P = 0.033). Stratification analysis revealed thatCYP24A1polymorphisms had strong relationships with CHD risk that were dependent on age, sex, Gensini grade and smoking status (P < 0.05). Moreover, a four-locus model (rs2762934, rs1570669, rs6068816 and rs2296241) had significant impact on CHD risk in MDR analysis. Conclusion It revealed thatCYP24A1variants were significantly linked with CHD susceptibility in the Chinese population.