Wnt Signaling in Stem Cell Maintenance and Differentiation in the Drosophila Germarium

被引：28
|
作者：
Waghmare, Indrayani [1 ]
Page-McCaw, Andrea
机构：
[1] Vanderbilt Univ, Sch Med, Dept Cell & Dev Biol, Nashville, TN 37240 USA
来源：
GENES | 2018年 / 9卷 / 03期
基金：
美国国家卫生研究院;
关键词：
Wnt; oocyte; follicle cell; escort cell; cap cell; differentiation niche; long-range signaling; stem cell niche; WINGLESS MORPHOGEN GRADIENT; EGG CHAMBER FORMATION; LONG-RANGE ACTION; PIRNA PATHWAY; NICHE SIGNALS; SELF-RENEWAL; GENE FAMILY; DALLY-LIKE; OVARY; GERMLINE;
D O I：
10.3390/genes9030127
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Wnt signaling is a conserved regulator of stem cell behaviors, and the Drosophila germarium has been an important model tissue for the study of stem cell maintenance, differentiation, and proliferation. Here we review Wnt signaling in the germarium, which houses two distinct types of ovarian stem cells: the anteriorly located germline stem cells (GSCs), which give rise to oocytes; and the mid-posteriorly located follicle stem cells (FSCs), which give rise to the somatic follicle cells that cover a developing oocyte. The maintenance and proliferation of GSCs and FSCs is regulated by the stem cell niches, whereas differentiation of the germline is regulated by the differentiation niche. Four distinct Wnt ligands are localized in the germarium, and we focus review on how these Wnt ligands and Wnt signaling affects maintenance and differentiation of both germline and follicle stem cells in their respective niches.
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页数：14
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