The role of fetuin-A in cardiovascular diseases

被引：6
|
作者：
Voeroes Krisztian [1 ]
Cseh Karoly [2 ]
Kalabay Laszlo [1 ]
机构：
[1] Semmelweis Egyet, Altalanos Orvostudomanyi Kar, Csaladorvosi Tanszek, Budapest, Hungary
[2] Semmelweis Egyet, Altalanos Orvostudomanyi Kar, Nepegeszsegtani Intezet, Budapest, Hungary
来源：
ORVOSI HETILAP | 2014年 / 155卷 / 01期
关键词：
fetuin-A; insulin resistance; adipocyte dysfunction; arterial calcification; cardiovascular disease; ALPHA(2)-HEREMANS-SCHMID GLYCOPROTEIN/FETUIN-A; FATTY LIVER-DISEASE; INSULIN-RESISTANCE; SERUM; ASSOCIATION; CALCIFICATION; EXPRESSION; PROTEIN; HEART; RISK;
D O I：
10.1556/OH.2014.29793
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Fetuin-A (also known as alpha(2)-Heremans-Schmid glycoprotein) is a multifunctional molecule secreted by the liver. It is a negative acute phase reactant with a debated role in subclinical inflammation. Fetuin-A is an inhibitor of the insulin receptor and its serum level correlates with insulin resistance. The protein has been implicated in adipocyte dysfunction and it is associated with obesity and non-alcoholic fatty liver disease. Although all these properties seem to promote atherosclerosis, the role of fetuin-A in cardiovascular diseases is more complex. As a natural inhibitor of tissue and vascular calcification, fetuin-A also acts as a protective factor in atherosclerosis. The potential role and prognostic value of fetuin-A in arterial calcification and cardiovascular diseases is discussed in this review, along with explanations for seemingly contradicting results in the literature and possible directions for future research.
引用
收藏
页码：16 / 23
页数：8
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