Synthesis, antibacterial, and antitubercular studies of some novel isatin derivatives

被引：8
|
作者：
Murali, K. [1 ]
Avinash, R. [2 ]
Kirthiga, R. [3 ]
Franzblau, Scott G. [4 ]
机构：
[1] Univ Rovira & Virgili, Dept Chem Engn, Tarragona 43007, Spain
[2] CL Baid Metha Coll Pharm, Dept Pharmaceut Chem, Madras 600097, Tamil Nadu, India
[3] Bangalore Antibiot & Biol Pvt Ltd, Salem 636007, Tamil Nadu, India
[4] Univ Illinois, Inst TB Res, Chicago, IL USA
来源：
MEDICINAL CHEMISTRY RESEARCH | 2012年 / 21卷 / 12期
关键词：
Antitubercular; Antibacterial; Isatin; Mannich bases; MANNICH-BASES; ANTIMICROBIAL ACTIVITY; ANTIBIOTIC-RESISTANCE; ACID;
D O I：
10.1007/s00044-012-9971-7
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The rise in clinical significance of multi drug-resistant bacterial pathogens has directed us to synthesize a novel series of isatin derivatives and characterize them by IR, NMR, mass spectral, and elemental analysis. Compounds were evaluated for their preliminary in vitro antibacterial activity against Gram-positive (Staphylococcus aureus, Staphylococcus epidermis, Micrococcus luteus, Bacillus cereus) bacteria and were screened for antitubercular activity against Mycobacterium tuberculosis H37Rv strain by microplate alamar blue assay (MABA) method. Some synthesized compounds showed very good antibacterial and antitubercular activities.
引用
收藏
页码：4335 / 4340
页数：6
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