Evaluation of Immunohistochemical Markers of Lymphatic and Blood Vessels in Canine Mammary Tumours

被引：15

作者：

Sleeckx, N. ^{[1
]}

Van Brantegem, L. ^{[2
]}

Fransen, E. ^{[3
]}

Van den Eynden, G. ^{[4
]}

Casteleyn, C. ^{[1
]}

Kroeze, E. Veldhuis ^{[5
]}

Van Ginneken, C. ^{[1
]}

机构：

[1] Univ Antwerp, Dept Vet Sci, B-2610 Antwerp, Belgium

[2] Univ Ghent, Fac Vet Med, Dept Pathol Bacteriol & Poultry Dis, B-9820 Merelbeke, Belgium

[3] Univ Antwerp, StatUa Ctr Stat, B-2650 Edegem, Belgium

[4] GZA Hosp, Dept Pathol & Cytol, B-2610 Antwerp, Belgium

[5] Erasmus MC, Dept Virol, NL-3015 GE Rotterdam, Netherlands

来源：

JOURNAL OF COMPARATIVE PATHOLOGY | 2013年 / 148卷 / 04期

关键词：

blood vessel; immunohistochemistry; lymphatic vessel; canine mammary tumour; SQUAMOUS-CELL CARCINOMAS; BREAST-CANCER; MICROVESSEL DENSITY; INTERNATIONAL CONSENSUS; PROGNOSTIC-SIGNIFICANCE; ANGIOGENESIS; LYMPHANGIOGENESIS; GROWTH; QUANTIFICATION; EXPRESSION;

D O I：

10.1016/j.jcpa.2012.09.007

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Canine mammary tumours (CMTs) are the most common neoplasms in intact female dogs. Bitches with spontaneously arising CMTs represent a promising animal model for human breast cancer research. The aim of the present study was to develop an immunohistochemical protocol for the identification of blood and lymphatic vessels in CMTs. Antibodies specific for human lymphatic vessels (prox-1, lyve-1, podoplanin and D2-40) and blood vessels (von Willebrand factor [vWf], CD31 and CD34) were utilized. Serial sections of 18 samples (eight samples of normal canine mammary tissue, five benign and five malignant CMTs) were examined. Antibodies specific for podoplanin, D2-40 and CD34 showed no immunoreactivity with canine tissue. Prox-1 and CD31 were determined to be the most suitable markers for lymphatic and blood vessels, respectively. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：307 / 317

页数：11

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