Detection of a quantitative trait locus for intramuscular fat accumulation using the OLETF rat

被引：18
|
作者：
Tanomura, H
Miyake, T
Taniguchi, Y
Manabe, N
Kose, H
Matsumoto, K
Yamada, T
Sasaki, Y [1 ]
机构：
[1] Kyoto Univ, Grad Sch Agr, Lab Anim Breeding & Genet, Sakyo Ku, Kyoto 6068502, Japan
[2] Kyoto Univ, Grad Sch Agr, Lab Anat & Cell Biol, Sakyo Ku, Kyoto 6068502, Japan
[3] Univ Tokushima, Sch Med, Inst Anim Expt, Tokushima 7708503, Japan
来源：
JOURNAL OF VETERINARY MEDICAL SCIENCE | 2002年 / 64卷 / 01期
关键词：
animal model; intramuscular fat; obesity; OLETF rat; QTL;
D O I：
10.1292/jvms.64.45
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
The Otsuka Long-Evans Tokushima Fatty (OLETF) rat is an animal model for obese type 2 diabetes. We showed that the OLETF rat exhibits higher levels of intramuscular fat content in Musculus longissimus as compared to the Fischer-344 (F344) rat. Our investigation was designed to identify quantitative trait loci (QTLs) contributing to the increased levels of intramuscular fat content by performing a whole-genome search using 108 F, intercross obtained by mating the OLETF and the F344 rats. We identified one QTL responsible for intramuscular fat accumulation on rat chromosome I with a maximum led score of 3.4, which accounts for 5% of the total variance. As expected, the OLETF allele corresponds to the increased levels of intramuscular fat content.
引用
收藏
页码：45 / 50
页数：6
相关论文
共 50 条
  • [1] Quantitative Trait Gene Responsible for Intramuscular Fat Content in the Rat
    Tanomura, Hideki
    Yamamoto, Takuji
    Muramatsu, Youji
    Ohta, Takeshi
    Yamada, Takahisa
    [J]. JOURNAL OF ANIMAL AND VETERINARY ADVANCES, 2011, 10 (07): : 841 - 846
  • [2] Identification of a quantitative trait locus influencing plasma insulin levels after 70% pancreatectomy using the OLETF rat
    Moralejo, DH
    Ogino, T
    Zhu, M
    Toide, K
    Wei, SW
    Wei, KC
    Yamada, T
    Mizuno, A
    Matsumoto, K
    Shima, K
    [J]. JOURNAL OF VETERINARY MEDICAL SCIENCE, 1998, 60 (10): : 1157 - 1160
  • [3] Genetic dissection of "OLETF," a rat model for non-insulin-dependent diabetes mellitus: Quantitative trait locus analysis of (OLETF x BN) x OLETF
    Watanabe, TK
    Okuno, S
    Oga, K
    Mizoguchi-Miyakita, A
    Tsuji, A
    Yamasaki, Y
    Hishigaki, H
    Kanemoto, N
    Takagi, T
    Takahashi, E
    Irie, Y
    Nakamura, Y
    Tanigami, A
    [J]. GENOMICS, 1999, 58 (03) : 233 - 239
  • [4] Haplotype analysis within quantitative trait locus affecting intramuscular fat content on porcine chromosome 7
    Sato, S.
    Ohnishi, C.
    Uemoto, Y.
    Kobayashi, E.
    [J]. CZECH JOURNAL OF ANIMAL SCIENCE, 2011, 56 (12) : 521 - 528
  • [5] Detection of quantitative trait loci for backfat thickness and intramuscular fat content in pigs (Sus scrofa)
    de Koning, DJ
    Janss, LLG
    Rattink, AP
    van Oers, PAM
    de Vries, BJ
    Groenen, MAM
    van der Poel, JJ
    de Groot, PN
    Brascamp, EW
    van Arendonk, JAM
    [J]. GENETICS, 1999, 152 (04) : 1679 - 1690
  • [6] A congenic strain (F344.OLETF-Imfm) displays the existence of intramuscular fat accumulation QTL on rat chromosome 1
    Tanomura, H
    Taniguchi, Y
    Muramatsu, Y
    Kose, H
    Miyake, T
    Matsumoto, K
    Yamada, T
    Sasaki, Y
    [J]. EXPERIMENTAL ANIMALS, 2003, 52 (04) : 303 - 308
  • [7] Quantitative trait locus detection using combined linkage/disequilibrium analysis
    Almasy, L
    Williams, JT
    Dyer, TD
    Blangero, J
    [J]. GENETIC EPIDEMIOLOGY, 1999, 17 : S31 - S36
  • [8] Identification of quantitative trait loci for NIDDM that interact with body weight in the OLETF rat
    Wei, SW
    Moralejo, DH
    Wei, KC
    Zangen, SW
    Koike, G
    Jacib, HJ
    Hirashima, T
    Kawano, K
    Sugiura, K
    Sasaki, Y
    Yamada, T
    Matsumoto, K
    [J]. DIABETES, 1998, 47 : A171 - A171
  • [9] A quantitative trait locus influencing anxiety in the laboratory rat
    Flint, J
    Fernández-Teruel, A
    Escorihuela, RM
    Gray, JA
    Aguilar, R
    Gil, L
    Giménez-Llort, L
    Tobeña, A
    Bomhra, A
    Nicod, A
    Mott, R
    Driscoll, P
    Dawson, GR
    [J]. BEHAVIOR GENETICS, 2002, 32 (06) : 464 - 464
  • [10] A quantitative trait locus influencing anxiety in the laboratory rat
    Fernández-Teruel, A
    Escorihuela, RM
    Gray, JA
    Aguilar, R
    Gil, L
    Giménez-Llort, L
    Tobeña, A
    Bhomra, A
    Nicod, A
    Mott, R
    Driscoll, P
    Dawson, GR
    Flint, J
    [J]. GENOME RESEARCH, 2002, 12 (04) : 618 - 626
12345