Renal stem cells: fact or science fiction?

被引：49
|
作者：
McCampbell, Kristen K. [1 ]
Wingert, Rebecca A. [1 ]
机构：
[1] Univ Notre Dame, Dept Biol Sci, Notre Dame, IN 46556 USA
来源：
BIOCHEMICAL JOURNAL | 2012年 / 444卷
基金：
美国国家卫生研究院;
关键词：
kidney; kidney development; kidney disease; neonephrogenesis; regeneration; repair; stem cell; SIDE POPULATION CELLS; PROGENITOR-LIKE CELLS; ACUTE KIDNEY INJURY; EPITHELIAL-CELLS; PROXIMAL TUBULE; ADULT KIDNEY; INTERMEDIATE MESODERM; STEM/PROGENITOR CELLS; CHRONIC NEPHROPATHIES; CONGENITAL-ANOMALIES;
D O I：
10.1042/BJ20120176
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The kidney is widely regarded as an organ without regenerative abilities. However, in recent years this dogma has been challenged on the basis of observations of kidney recovery following acute injury, and the identification of renal populations that demonstrate stem cell characteristics in various species. It is currently speculated that the human kidney can regenerate in some contexts, but the mechanisms of renal regeneration remain poorly understood. Numerous controversies surround the potency, behaviour and origins of the cell types that are proposed to perform kidney regeneration. The present review explores the current understanding of renal stem cells and kidney regeneration events, and examines the future challenges in using these insights to create new clinical treatments for kidney disease.
引用
收藏
页码：153 / 168
页数：16
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