Antitumor Activities and Pharmacodynamic Biomarkers of a Novel and Orally Available Small Molecule IAP Antagonist

被引：0
|
作者：
Sumi, H.
Yabuki, M.
Iwai, K.
Hashimoto, K.
Kosugi, Y.
Yoshimatsu, M.
Ishikawa, T.
Yoshida, S.
机构：
来源：
EUROPEAN JOURNAL OF CANCER | 2012年 / 48卷
关键词：
D O I：
10.1016/S0959-8049(12)71871-3
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
73
引用
收藏
页码：24 / 24
页数：1
相关论文
共 50 条
  • [1] Antitumor Activity and Pharmacodynamic Biomarkers of a Novel and Orally Available Small-Molecule Antagonist of Inhibitor of Apoptosis Proteins
    Sumi, Hiroyuki
    Yabuki, Masato
    Iwai, Kenichi
    Morimoto, Megumi
    Hibino, Ryosuke
    Inazuka, Masakazu
    Hashimoto, Kentaro
    Kosugi, Yohei
    Aoyama, Kazunobu
    Yamamoto, Shunsuke
    Yoshimatsu, Mie
    Yamasaki, Hideki
    Tozawa, Ryuichi
    Ishikawa, Tomoyasu
    Yoshida, Sei
    MOLECULAR CANCER THERAPEUTICS, 2013, 12 (02) : 230 - 240
  • [2] Potent antitumor activity of a novel and orally available small -molecule antagonist targeting the CD47/SIRPα pathway
    Sasikumar, Pottayil G.
    Gundala, Chennakrishnareddy
    Balasubramanian, Wesley R.
    Naremaddepalli, Sudarshan S.
    Bhumireddy, Archana
    Patil, Sandeep S.
    Dhudashiya, Amit A.
    Rayavarapu, Vijaysai
    Lakshminarasimhan, Anirudha
    Samiulla, Dodheri S.
    Aithal, Kiran
    Daginakatte, Girish
    Ramachandra, Murali
    MOLECULAR CANCER THERAPEUTICS, 2018, 17 (01)
  • [3] T-3256336, a novel and orally available small molecule IAP antagonist, induced tumor cell death via induction of systemic TNF alpha production
    Sumi, Hiroyuki
    Inazuka, Masakazu
    Hashimoto, Kentaro
    Ishikawa, Tomoyasu
    Yoshida, Sei
    Yabuki, Masato
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2016, 479 (02) : 179 - 185
  • [4] Identification of novel orally available small molecule insulin mimetics
    Lin, Bo
    Li, Zhitao
    Park, Kaapjoo
    Deng, Liu
    Pai, Ashok
    Zhong, Ling
    Pirrung, Michael C.
    Webster, Nicholas J. G.
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2007, 323 (02): : 579 - 585
  • [5] In vitro and in vivo antitumor activities of T-3764518, a novel and orally available small molecule stearoyl-CoA desaturase 1 inhibitor
    Nishizawa, Satoru
    Sumi, Hiroyuki
    Satoh, Yoshihiko
    Yamamoto, Yukiko
    Kitazawa, Satoshi
    Honda, Kohei
    Araki, Hideo
    Kakoi, Kazuyo
    Imamura, Keisuke
    Sasaki, Masako
    Miyahisa, Ikuo
    Satomi, Yoshinori
    Nishigaki, Ryuuichi
    Hirayama, Megumi
    Aoyama, Kazunobu
    Maezaki, Hironobu
    Hara, Takahito
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2017, 807 : 21 - 31
  • [6] Potent antitumor activity of small molecule IAP antagonists
    Chunduru, S.
    Condon, S.
    Benetatos, C.
    Burns, J.
    Deng, Y.
    LaPorte, M.
    Springs, S.
    Shi, Y.
    McKinlay, M.
    EJC SUPPLEMENTS, 2006, 4 (12): : 112 - 112
  • [7] A novel orally available small molecule that inhibits hepatitis B virus expression
    Mueller, Henrik
    Wildum, Steffen
    Luangsay, Souphalone
    Walther, Johanna
    Lopez, Anais
    Tropberger, Philipp
    Ottaviani, Giorgio
    Lu, Wenzhe
    Parrott, Neil John
    Zhang, Jitao David
    Schmucki, Roland
    Racek, Tomas
    Hoflack, Jean-Christophe
    Kueng, Erich
    Point, Floriane
    Zhou, Xue
    Steiner, Guido
    Luetgehetmann, Marc
    Rapp, Gianna
    Volz, Tassilo
    Dandri, Maura
    Yang, Song
    Young, John A. T.
    Javanbakht, Hassan
    JOURNAL OF HEPATOLOGY, 2018, 68 (03) : 412 - 420
  • [8] In vivo evaluation of a novel, orally bioavailable, small molecule growth hormone receptor antagonist
    Rosengren, Linda
    Parrow, Vendela
    Chmielewska, Joanna
    Mode, Agneta
    Fholenhag, Karin
    GROWTH HORMONE & IGF RESEARCH, 2007, 17 (01) : 47 - 53
  • [9] Antitumor activity of a novel and orally available inhibitor of serine palmitoyltransferase
    Yaguchi, Masahiro
    Shibata, Sachio
    Satomi, Yoshinori
    Hirayama, Megumi
    Adachi, Ryutaro
    Asano, Yasutomi
    Kojima, Takuto
    Hirata, Yasuhiro
    Mizutani, Akio
    Kiba, Atsushi
    Sagiya, Yoji
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2017, 484 (03) : 493 - 500
  • [10] Reversal of pancreatitis-induced pain by an orally available, small molecule interleukin-6 receptor antagonist
    Vardanyan, Marina
    Melemedjian, Ohannes K.
    Price, Theodore J.
    Ossipov, Michael H.
    Lai, Josephine
    Roberts, Ed
    Boos, Terrence L.
    Deschamps, Jeffrey R.
    Jacobson, Arthur E.
    Rice, Kenner C.
    Porreca, Frank
    PAIN, 2010, 151 (02) : 257 - 265
12345