Serum salusin-α levels are inversely correlated with the presence and severity of coronary artery disease

We sought to measure serum salusin-alpha levels in patients with coronary artery disease (CAD) and to assess their correlation with the severity of the disease. We enrolled 172 patients with CAD and 91 controls. We assessed the angiographic severity of CAD by coronary atherosclerosis index (CAI) and detected serum salusin-alpha levels by enzyme-linked immunosorbent assay (ELISA). We demonstrated that CAD patients had significantly lower serum salusin-alpha levels compared to controls. Moreover, serum salusin-alpha levels were independently and negatively correlated with the presence and severity of CAD. These findings indicated that salusin-alpha might serve as a potential biomarker for predicting the development and progression of CAD.