Thin-layer chromatography and mass spectrometry for screening of biological samples for drugs and metabolites

被引：0
|
作者：
Brzezinka, H
Dallakian, P
Budzikiewicz, H
机构：
[1] Univ Bonn, Inst Rechtsmed, D-53111 Bonn, Germany
[2] Univ Cologne, Inst Organ Chem, D-50939 Cologne, Germany
来源：
JPC-JOURNAL OF PLANAR CHROMATOGRAPHY-MODERN TLC | 1999年 / 12卷 / 02期
关键词：
off-line TLC-MS; El mass spectrometry; drugs; metabolites;
D O I：
暂无
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
This paper describes a method for off-line coupling of thin-layer chromatography (TLC) and electron-impact ionization mass spectrometry (EIMS) which is well suited for routine forensic and toxicological investigations of a large number of samples. The advantages and drawbacks of this approach are discussed. Several TLC systems for 493 compounds of forensic and toxicological interest are described and eight-peak mass spectra from full EI mass spectra are listed.
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页码：96 / 108
页数：13
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