Biomechanical Profiling of Caenorhabditis elegans Motility

被引：38
|
作者：
Krajacic, Predrag [1 ]
Shen, Xiaoning [2 ]
Purohit, Prashant K. [2 ]
Arratia, Paulo [2 ]
Lamitina, Todd [1 ]
机构：
[1] Univ Penn, Dept Physiol, Philadelphia, PA 19104 USA
[2] Univ Penn, Dept Mech Engn & Appl Mech, Philadelphia, PA 19104 USA
来源：
GENETICS | 2012年 / 191卷 / 03期
基金：
美国国家科学基金会; 美国国家卫生研究院;
关键词：
RECEPTOR; PROPULSION; ENCODES;
D O I：
10.1534/genetics.112.141176
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Caenorhabditis elegans locomotion is a stereotyped behavior that is ideal for genetic analysis. We integrated video microscopy, image analysis algorithms, and fluid mechanics principles to describe the C. elegans swim gait. Quantification of body shapes and external hydrodynamics and model-based estimates of biomechanics reveal that mutants affecting similar biological processes exhibit related patterns of biomechanical differences. Therefore, biomechanical profiling could be useful for predicting the function of previously unstudied motility genes.
引用
收藏
页码：1015 / U613
页数：9
相关论文
共 50 条
  • [1] Fluorescent Polysome Profiling in Caenorhabditis elegans
    Shaffer, Dan
    Rollins, Jarod
    [J]. BIO-PROTOCOL, 2020, 10 (17):
  • [2] THE DEVELOPMENT AND MOTILITY OF CAENORHABDITIS-ELEGANS SPERMATOZOA
    WARD, S
    ROBERTS, TM
    NELSON, GA
    ARGON, Y
    [J]. JOURNAL OF NEMATOLOGY, 1982, 14 (02) : 259 - 266
  • [3] Biomechanical analysis of gait adaptation in the nematode Caenorhabditis elegans
    Fang-Yen, Christopher
    Wyart, Matthieu
    Xie, Julie
    Kawai, Risa
    Kodger, Tom
    Chen, Sway
    Wen, Quan
    Samuel, Aravinthan D. T.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (47) : 20323 - 20328
  • [4] Global profiling of protein lactylation in Caenorhabditis elegans
    Ding, Tao
    Yang, Ye-Hong
    Wang, Qiao-Chu
    Wu, Yue
    Han, Rong
    Zhang, Xu-Tong
    Kong, Jie
    Yang, Jun-Tao
    Liu, Jiang-Feng
    [J]. PROTEOMICS, 2024, 24 (1-2)
  • [5] Effects of commercial beverages on the neurobehavioral motility of Caenorhabditis elegans
    Zhang, Wenjing
    Zhang, Nan
    Zheng, Shan
    Zhang, Wei
    Liu, Jingjing
    He, Liwei
    Ezemaduka, Anastasia Ngozi
    Li, Guojun
    Ning, Junyu
    Xian, Bo
    Gao, Shan
    [J]. PEERJ, 2022, 10
  • [6] Expression profiling of GABAergic motor neurons in Caenorhabditis elegans
    Cinar, H
    Keles, S
    Jin, YS
    [J]. CURRENT BIOLOGY, 2005, 15 (04) : 340 - 346
  • [7] Chemoproteomic Profiling of O-GlcNAcylation in Caenorhabditis elegans
    Qin, Wei
    Xie, Zhongyun
    Wang, Jingyang
    Ou, Guangshuo
    Wang, Chu
    Chen, Xing
    [J]. BIOCHEMISTRY, 2020, 59 (34) : 3129 - 3134
  • [8] Metabolic profiling of a transgenic Caenorhabditis elegans Alzheimer model
    Roel Van Assche
    Liesbet Temmerman
    Daniel A. Dias
    Berin Boughton
    Kurt Boonen
    Bart P. Braeckman
    Liliane Schoofs
    Ute Roessner
    [J]. Metabolomics, 2015, 11 : 477 - 486
  • [9] Whole-Genome Profiling of Mutagenesis in Caenorhabditis elegans
    Flibotte, Stephane
    Edgley, Mark L.
    Chaudhry, Iasha
    Taylor, Jon
    Neil, Sarah E.
    Rogula, Aleksandra
    Zapf, Rick
    Hirst, Martin
    Butterfield, Yaron
    Jones, Steven J.
    Marra, Marco A.
    Barstead, Robert J.
    Moerman, Donald G.
    [J]. GENETICS, 2010, 185 (02) : 431 - 441
  • [10] Metabolic profiling of a transgenic Caenorhabditis elegans Alzheimer model
    Van Assche, Roel
    Temmerman, Liesbet
    Dias, Daniel A.
    Boughton, Berin
    Boonen, Kurt
    Braeckman, Bart P.
    Schoofs, Liliane
    Roessner, Ute
    [J]. METABOLOMICS, 2015, 11 (02) : 477 - 486
12345