No association between AKT1 gene variants and schizophrenia: A Malaysian case-control study and meta-analysis

被引：4
|
作者：
Loh, Han Chern [1 ,2 ]
Chow, Tze Jen [1 ]
Tang, Pek Yee [3 ]
Sen Yong, Hoi [4 ]
机构：
[1] Univ Tunku Abdul Rahman, Fac Engn & Sci FES, Dept Chem Engn, Kuala Lumpur 53300, Malaysia
[2] Univ Malaya, High Impact Res Off, Kuala Lumpur 50603, Malaysia
[3] UTAR, FES, Dept Biomed Engn, Kuala Lumpur 53300, Malaysia
[4] UM, Fac Sci, Inst Biol Sci, Kuala Lumpur 50603, Malaysia
来源：
PSYCHIATRY RESEARCH | 2013年 / 209卷 / 03期
关键词：
Haplotype; rs2494732; Ethnic analysis; CANDIDATE GENES; POPULATION; HAPLOTYPE; SAMPLE; RISK;
D O I：
10.1016/j.psychres.2013.05.017
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
We aim to replicate AKT1 gene variants studies using Malaysian samples. Seven AKT1 single nucleotide polymorphisms (SNPs) were studied in 417 patients and 429 controls. Haplotype showed significant association (p=0.036) with schizophrenia, especially in Malays and Indians. Meta-analysis of rs2494732 showed significant association worldwide (p=0.018) and in Asians (p=0.023). (C) 2013 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：732 / 733
页数：2
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