A Mathematical Model of Mitotic Exit in Budding Yeast: The Role of Polo Kinase

被引：9

作者：

Hancioglu, Baris ^{[1
]}

Tyson, John J. ^{[1
]}

机构：

[1] Virginia Polytech Inst & State Univ, Dept Biol Sci, Blacksburg, VA 24061 USA

来源：

PLOS ONE | 2012年 / 7卷 / 02期

基金：

美国国家卫生研究院;

关键词：

ANAPHASE-PROMOTING COMPLEX; QUANTIZED CYCLE TIMES; CELL-CYCLE; SACCHAROMYCES-CEREVISIAE; CDC14; RELEASE; FISSION YEAST; M-PHASE; PHOSPHATASE CDC14; SPINDLE CHECKPOINT; DNA-REPLICATION;

D O I：

10.1371/journal.pone.0030810

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cell cycle progression in eukaryotes is regulated by periodic activation and inactivation of a family of cyclin-dependent kinases (Cdk's). Entry into mitosis requires phosphorylation of many proteins targeted by mitotic Cdk, and exit from mitosis requires proteolysis of mitotic cyclins and dephosphorylation of their targeted proteins. Mitotic exit in budding yeast is known to involve the interplay of mitotic kinases (Cdk and Polo kinases) and phosphatases (Cdc55/PP2A and Cdc14), as well as the action of the anaphase promoting complex (APC) in degrading specific proteins in anaphase and telophase. To understand the intricacies of this mechanism, we propose a mathematical model for the molecular events during mitotic exit in budding yeast. The model captures the dynamics of this network in wild-type yeast cells and 110 mutant strains. The model clarifies the roles of Polo-like kinase (Cdc5) in the Cdc14 early anaphase release pathway and in the G-protein regulated mitotic exit network.

引用

页数：16

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