Genetics, Epigenetics, and Genomics of Systemic Sclerosis

被引:23
|
作者
Salazar, Gloria [1 ]
Mayes, Maureen D. [1 ]
机构
[1] Univ Texas Hlth Sci Ctr Houston, Div Rheumatol & Clin Immunogenet, Houston, TX 77030 USA
关键词
Genetics; Epigenetics; Systemic sclerosis; Scleroderma; Gene expression; microRNA; miRNA; Splicing; I COLLAGEN EXPRESSION; WIDE ASSOCIATION; RISK-FACTOR; DOWN-REGULATION; INDEPENDENT REPLICATION; FUNCTIONAL POLYMORPHISM; DERMAL FIBROBLASTS; SUSCEPTIBILITY; DISEASE; REGION;
D O I
10.1016/j.rdc.2015.04.001
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Systemic sclerosis (SSc) is a complex autoimmune disease that occurs in a genetically susceptible host. Genetic studies performed so far reveal that multiple genetic loci contribute to disease susceptibility in SSc. The purpose of this review is to discuss the current knowledge of genetics in SSc by exploring the observational evidence, the different genetic studies, and their modalities as well as the most relevant genes discovered by these. The importance of gene expression variation and the different mechanisms that govern it, including the recently discovered field of epigenetics, are also explored, with an emphasis on microRNA.
引用
收藏
页码:345 / +
页数:23
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