Overriding the Immune System's Sweet Tooth: Fatty Acids Rile Up Innate Immunity

被引：5

作者：

Billi, Allison C. ^{[1
]}

Gudjonsson, Johann E. ^{[1
]}

机构：

[1] Univ Michigan, Sch Med, Dept Dermatol, Ann Arbor, MI 48109 USA

来源：

CELL | 2019年 / 177卷 / 05期

关键词：

PSORIASIS;

D O I：

10.1016/j.cell.2019.04.033

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mogilenko et al. dissect mechanisms by which fatty acids lead to a state of heightened innate immunity and inflammation. They reveal a metabolic adaptation to elevated fatty acids that involves a shift in the balance between glycolysis and oxidative phosphorylation and activation of the unfolded protein response, linking the high-fat Western diet to systemic inflammatory disease.

引用

页码：1088 / 1090

页数：4

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