A fatal effect of hornet venom on rat-brain cortical neurons

被引：3
|
作者：
Cohen-Armon, Malka [1 ]
Visochek, Leonid
Priel, Esther
Ishay, Jacob S.
机构：
[1] Tel Aviv Univ, Sackler Fac Med, Dept Physiol & Pharmacol, IL-69978 Tel Aviv, Israel
[2] Ben Gurion Univ Negev, Fac Hlth Sci, Dept Microbiol & Immunol, IL-84105 Beer Sheva, Israel
[3] Tel Aviv Univ, Neufeld Cardiac Res Inst, Shiba Hosp, Sackler Fac Med, IL-69978 Tel Aviv, Israel
来源：
CHEMISTRY & BIODIVERSITY | 2006年 / 3卷 / 05期
关键词：
D O I：
10.1002/cbdv.200690057
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In a previous study, it was shown that the hornet venom or, more specifically, its venom sac extract (VSE) possesses deoxyribonuclease activity that exerts an effect both on insects as well as on mammals. We have now examined the effect of hornet VSE on primary culture of rat cortical neurons. Judging on the basis of our results, VSE induces a rapid cell death by a) permeabilizing the cell membrane, b) inducing DNA breaks, and c) cleaving the nuclear protein poly-ADP-ribose polymerase (PARP-1), thereby preventing DNA repair.
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页码：535 / 543
页数：9
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