C-reactive protein and homocysteine are associated with dietary and behavioral risk factors for age-related macular degeneration

被引:55
|
作者
Seddon, JM [1 ]
Gensler, G
Klein, ML
Milton, RC
机构
[1] Harvard Univ, Sch Med, Dept Ophthalmol, Epidemiol Unit,Massachusetts Eye & Ear Infirm, Boston, MA 02115 USA
[2] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA
[3] EMMES Corp, Rockville, MD USA
[4] Devers Eye Inst, Portland, OR USA
[5] Casey Eye Inst, Portland, OR USA
关键词
age-related macular degeneration; biomarkers; C-reactive protein; homocysteine; diet; lutein/zeaxanthin; fish intake; body mass index; smoking;
D O I
10.1016/j.nut.2005.12.004
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Objective: We investigated whether age-related macular degeneration risk factors are associated with high-sensitivity C-reactive protein (CRP) and homocysteine (HCY), systemic biomarkers for cardiovascular disease. Methods: Subjects with a range of age-related macular maculopathies or no maculopathy at two centers in the United States were evaluated. Risk factors and biomarkers were assessed by questionnaire, direct measurement, or analyses of blood specimens. Results: Higher levels of serum antioxidants vitamin C and lutein/zeaxanthin and higher fish intake were associated with lower serum CRP levels, whereas serum vitamin E, smoking, and increased body mass index were associated with increased CRP. Serum vitamin E, serum a-carotene, and dietary intake of antioxidants and vitamin 86 were associated with lower levels of plasma HCY, whereas hypertension was associated with increased HCY. Conclusions: C-reactive protein and HCY levels are related to traditional dietary and behavioral factors associated with age-related macular degeneration. (c) 2006 Elsevier Inc. All rights reserved.
引用
收藏
页码:441 / 443
页数:3
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