Effect of acute and short-term oral salbutamol treatments on maximal power output in non-asthmatic athletes

被引:28
|
作者
Sanchez, Anthony M. J. [1 ]
Collomp, Katia [2 ]
Carra, Juliette [1 ]
Borrani, Fabio [3 ]
Coste, Olivier [4 ]
Prefaut, Christian [5 ]
Candau, Robin [1 ]
机构
[1] Univ Montpellier I, Fac Sci Sport, INRA, UMR866, F-34060 Montpellier, France
[2] AFLD, Dept Anal, Orleans, France
[3] Univ Auckland, Dept Sport & Exercise Sci, Auckland 1, New Zealand
[4] Direct Reg Jeunesse Sports & Cohes Sociale Langue, Montpellier, France
[5] CHU Montpellier, INSERM, F-1046 Montpellier, France
关键词
beta(2)-Agonist; Doping; Force-velocity relationship; Anaerobic performance; Lactate; Healthy athletes; SKELETAL-MUSCLE; SUPRAMAXIMAL EXERCISE; WINGATE TEST; RATS; PERFORMANCE; ALBUTEROL; CLENBUTEROL; ADAPTATION; SALMETEROL; STRENGTH;
D O I
10.1007/s00421-011-2307-3
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
This study aimed to clarify the controversial effects of acute and short-term salbutamol (SAL) intake on sprint performance in healthy athletes. Based on the results of previous studies, an anabolic effect for the short-term treatment and increased glycolysis in both treatments were hypothesized. Eight male recreational athletes completed force-velocity exercise tests after administration of placebo (gelatin), acute oral SAL (6 mg) or short-term oral SAL (12 mg day(-1) for 3 weeks), using a double-blind and randomized protocol. A friction-loaded cycle ergometer fitted with a strain gauge, and an incremental encoder ensured accurate measurement of the force-velocity relationship during sprints. Mechanical data were averaged during each pedal downstroke. Compared with placebo after both acute and 3 weeks of continuous treatment, the force-velocity relationship shifted to the right with power output gains of 14 and 8% (p < 0.001), respectively. This effect was less marked for 3 weeks of continuous treatment compared with acute administration (p < 0.001), suggesting a down-regulation in adrenoceptors. Our first hypothesis thus seems rejected. Significantly higher end-of-exercise and recovery blood lactate concentrations were found under SAL compared with placebo (p < 0.001), supporting our second hypothesis. In conclusion, these data indicate that oral administration of SAL is an effective ergogenic aid for sprint exercise in non-asthmatic athletes. Moreover, an acute treatment seems to be more effective than 3 weeks of continuous treatment.
引用
收藏
页码:3251 / 3258
页数:8
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