The endocannabinoid 2-arachidonoylglycerol suppresses excitatory synaptic input to the dentate gyrus and ameliorates seizures

被引：0
|
作者：
Sugaya, Yuki [1 ]
Yamazaki, Maya [2 ]
Sakimura, Kenji [2 ]
Kano, Masanobu [1 ]
机构：
[1] Univ Tokyo, Grad Sch Med, Dept Neurophysiol, Tokyo 1138654, Japan
[2] Niigata Univ, Brain Res Inst, Dept Cellular Neurobiol, Niigata 95021, Japan
来源：
JOURNAL OF PHYSIOLOGICAL SCIENCES | 2013年 / 63卷
关键词：
D O I：
暂无
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
引用
收藏
页码：S149 / S149
页数：1
相关论文
共 50 条
  • [1] The Endocannabinoid 2-Arachidonoylglycerol Negatively Regulates Habituation by Suppressing Excitatory Recurrent Network Activity and Reducing Long-Term Potentiation in the Dentate Gyrus
    Sugaya, Yuki
    Cagniard, Barbara
    Yamazaki, Maya
    Sakimura, Kenji
    Kano, Masanobu
    JOURNAL OF NEUROSCIENCE, 2013, 33 (08): : 3588 - 3601
  • [2] Crucial Roles of the Endocannabinoid 2-Arachidonoylglycerol in the Suppression of Epileptic Seizures
    Sugaya, Yuki
    Yamazaki, Maya
    Uchigashima, Motokazu
    Kobayashi, Kenta
    Watanabe, Masahiko
    Sakimura, Kenji
    Kano, Masanobu
    CELL REPORTS, 2016, 16 (05): : 1405 - 1415
  • [3] Molecular-anatomical basis for the spread of endocannabinoid 2-arachidonoylglycerol at mossy cell-granule cell synapses in the dentate gyrus
    Uchigashima, Motokazu
    Watanabe, Masahiko
    NEUROSCIENCE RESEARCH, 2010, 68 : E55 - E55
  • [4] Biosynthesis and degradation of the endocannabinoid 2-arachidonoylglycerol
    Ueda, Natsuo
    Tsuboi, Kazuhito
    Uyama, Toru
    Ohnishi, Taira
    BIOFACTORS, 2011, 37 (01) : 1 - 7
  • [5] The endocannabinoid, 2-arachidonoylglycerol, has different effects on long-term potentiation in vivo between the dentate gyrus and the hippocampal CA1
    Sugaya, Yuki
    Tanimura, Asami
    Yamazaki, Maya
    Sakimura, Kenji
    Kano, Masanobu
    NEUROSCIENCE RESEARCH, 2011, 71 : E87 - E87
  • [6] The Endocannabinoid 2-Arachidonoylglycerol Produced by Diacylglycerol Lipase α Mediates Retrograde Suppression of Synaptic Transmission
    Tanimura, Asami
    Yamazaki, Maya
    Hashimotodani, Yuki
    Uchigashima, Motokazu
    Kawata, Shinya
    Abe, Manabu
    Kita, Yoshihiro
    Hashimoto, Kouichi
    Shimizu, Takao
    Watanabe, Masahiko
    Sakimura, Kenji
    Kano, Masanobu
    NEURON, 2010, 65 (03) : 320 - 327
  • [7] Tetrahydrolipstatin Analogues as Modulators of Endocannabinoid 2-Arachidonoylglycerol Metabolism
    Ortar, Giorgio
    Bisogno, Tiziana
    Ligresti, Alessia
    Morera, Enrico
    Nalli, Marianna
    Di Marzo, Vincenzo
    JOURNAL OF MEDICINAL CHEMISTRY, 2008, 51 (21) : 6970 - 6979
  • [8] The endocannabinoid 2-arachidonoylglycerol regulates platelet function.
    Baldassarri, Samantha
    Bertoni, Alessandra
    Lova, Paolo
    Reineri, Stefania
    Sarasso, Chiara
    Zanfa, Manuela
    Sanna, Elena
    Maccarrone, Mauro
    Torti, Mauro
    Sinigaglia, Fabiola
    BLOOD, 2006, 108 (11) : 53B - 53B
  • [9] Blockade of β-cell KATP channels by the endocannabinoid, 2-arachidonoylglycerol
    Spivak, Charles E.
    Kim, Wook
    Liu, Qing-Rong
    Lupica, Carl R.
    Doyle, Maire E.
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2012, 423 (01) : 13 - 18
  • [10] The endocannabinoid 2-arachidonoylglycerol inhibits endothelial function and repair
    Jehle, Julian
    Eich, Lukas
    Danisch, Melina
    Bagheri, Sayeh
    Avraamidou, Elina
    Pfeifer, Philipp
    Tiyerili, Vedat
    Bindila, Laura
    Lutz, Beat
    Nickenig, Georg
    INTERNATIONAL JOURNAL OF CARDIOLOGY, 2021, 323 : 243 - 250
12345