Establishment and characterization of induced pluripotent stem cells from placental mesenchymal stromal cells

被引：5

作者：

Parveen, Shagufta ^{[1
]}

机构：

[1] Manipal Univ, Sch Regenerat Med, GKVK Post,Bellary Rd, Bengaluru 560065, Karnataka, India

来源：

STEM CELL RESEARCH | 2018年 / 27卷

关键词：

Human term placenta; Placental mesenchymal stromal cells; Placental human induced pluripotent stem cells; Transgene free; Karyotypically normal; Teratoma;

D O I：

10.1016/j.scr.2017.12.008

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Human term placenta is a bulky organ which harbours abundant mesenchymal stromal cells. This study reports isolation and characterization of placental mesenchymal stromal cells (PMSCs) followed by reprogramming of PMSCs to induced pluripotent stem cells (iPSCs). The placental human iPSC (PhiPSC) line is pluripotent with high telomerase activity, genetically identical to parental PMSCs, transgene free, karyotypically normal and differentiates into ectoderm, mesoderm and endoderm both in vitro and in vivo. Thus PMSCs serve as a unique cell type for human perinatal iPSC derivation from extra embryonic tissue. (c) 2017 The Author(s). Published by Elsevier B.V.

引用

页码：15 / 20

页数：6

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