Serum IL-6 and IL-10 concentrations in bitches with pyometra undergoing ovariohysterectomy

被引：10
|
作者：
Dabrowski, Roman [1 ]
Pastor, Josep [2 ]
Szczubial, Marek [1 ]
Piech, Tomasz [1 ]
Bochniarz, Mariola [1 ]
Wawron, Wladyslaw [1 ]
Tvarijonaviciute, Asta [2 ,3 ]
机构：
[1] Univ Life Sci Lublin, Fac Vet Med, Dept & Clin Anim Reprod, PL-20612 Lublin, Poland
[2] Univ Autonoma Barcelona, Fac Vet Med, Dept Anim Med & Surg, E-08193 Barcelona, Spain
[3] Univ Murcia, Fac Vet Med, Dept Anim Med & Surg, Murcia, Spain
来源：
ACTA VETERINARIA SCANDINAVICA | 2015年 / 57卷
关键词：
Cytokines; Bitches; Pyometra; Ovariohysterectomy; Post surgery monitoring; C-REACTIVE PROTEIN; PLASMA ENDOTOXIN; DOGS; INTERLEUKIN-6; CYTOKINES; MARKERS;
D O I：
10.1186/s13028-015-0153-8
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
Background: Pyometra is a serious bacterial infection of the uterus affecting female dogs and manifests as an accumulation of pus in the uterine lumen. The aim of the study was to assess changes in serum interleukin (IL)-6 and IL-10 concentrations in bitches with pyometra undergoing ovariohysterectomy. Findings: Blood samples were collected from healthy bitches (controls) and bitches with pyometra before surgery, and 3 and 10 days after ovariohysterectomy. Before surgery, bitches with pyometra had significantly higher serum concentrations of IL-6 and IL-10 than the controls. After surgery, the serum concentration of IL-6 and IL-10 decreased significantly. In healthy dogs, the concentration of IL-6 and IL-10 showed a significant increase 3 days after surgery followed by a decrease on day 10. Conclusion: An increase in serum concentrations of IL-6 and IL-10 was present before surgery in bitches with pyometra and 3 days after ovariohysterectomy in healthy controls. Concentrations decreased after ovariohysterectomy and/or proper healing, suggesting that these cytokines can be useful for assessment of the postoperative period in bitches.
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页数：4
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