Effects of aluminum trichloride on the trace elements and cytokines in the spleen of rats

The bioaccumulation and immunotoxicity of aluminum (Al) have been previously documented. Al accumulates in the organs of the organism, including spleen. Spleen is a peripheral organ of the immune system. The accumulated Al may alter the immune function. Here, we investigated the bioaccumulation of Al in spleen and its alterations in the immune system. Forty male Wistar rats (5 weeks old) weighed 110-120 g were orally exposed to aluminum trichloride (AlCl3) (0, 64.18, 128.36 and 256.72 mg/kg body weight) in drinking water for 120 days. The concentrations of spleen's Al, iron (Fe), copper (Cu), zinc (Zn), interleukin-2 (IL-2), tumor necrosis factor-alpha (TNF-alpha) and growth index were examined at the end of the experiment. The results showed that the concentrations of Al and Cu in the spleen were increased in an AlCl3-dose dependent manner, and the concentrations of spleen's growth index, Fe, Zn, IL-2 and TNF-alpha were reduced in AlCl3-treated rats. The results suggest that AlCl3 can suppress the growth of spleen, disorder the balance of trace elements and inhibit the immune regulation of cytokines in the spleen. It indicates that AlCl3 suppresses the immune function of spleen. (C) 2012 Elsevier Ltd. All rights reserved.