Antibodies as a source of anti-infective peptides: an update

被引：9

作者：

Magliani, Walter ^{[1
]}

Giovati, Laura ^{[1
]}

Ciociola, Tecla ^{[1
]}

Sperinde, Martina ^{[1
]}

Santinoli, Claudia ^{[1
]}

Conti, Giorgio ^{[1
]}

Conti, Stefania ^{[1
]}

Polonelli, Luciano ^{[1
]}

机构：

[1] Univ Parma, Dept Biomed Biotechnol & Translat Sci, Microbiol & Virol Unit, I-43125 Parma, Italy

来源：

FUTURE MICROBIOLOGY | 2015年 / 10卷 / 07期

关键词：

antibodies; antibody-derived immunomodulatory peptides; antibody-derived anti-infective peptides; antibody-derived antitumor peptides; cryptides; microbicidal antibodies; therapeutic antibodies; DETERMINING REGIONS CDRS; KILLER PEPTIDE; MONOCLONAL-ANTIBODIES; THERAPEUTIC ACTIVITY; ANTIMICROBIAL PEPTIDES; BORRELIA-BURGDORFERI; HEAVY-CHAIN; ANTITUMOR; DRUGS; HIV-1;

D O I：

10.2217/fmb.15.36

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

This review focuses on antibodies (Abs) and their function in immune protection, with particular emphasis on microbicidal Abs. Some aspects of Abs and Ab-drug conjugates as targeting therapeutic agents are also discussed. The main aim, however, is devoted to Ab-derived peptides modulating functions of the immune system and to the latest experimental evidence of Abs as a source of anti-infective and antitumor peptides derived from their complementarity determining regions and constant regions.

引用

页码：1163 / 1175

页数：13

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