Atom-Economic Synthesis of Optically Active Warfarin Anticoagulant over a Chiral MOF Organocatalyst

被引：30

作者：

Shi, Tao ^{[1
,2
]}

Guo, Zhiwei ^{[1
,2
]}

Yu, Huixian ^{[1
,2
]}

Xie, Jianwu ^{[1
,2
]}

Zhong, Yijun ^{[1
,2
]}

Zhu, Weidong ^{[1
,2
]}

机构：

[1] Zhejiang Normal Univ, Inst Phys Chem, Minist Educ Adv Catalysis Mat, Key Lab, Jinhua 321004, Peoples R China

[2] Zhejiang Normal Univ, Dept Chem & Life Sci, Jinhua 321004, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2013年 / 355卷 / 13期

基金：

中国国家自然科学基金;

关键词：

asymmetric synthesis; catalyst design; heterogeneous catalysis; Michael addition; warfarin; METAL-ORGANIC FRAMEWORKS; HETEROGENEOUS ASYMMETRIC CATALYSIS; CYCLIC 1,3-DICARBONYL COMPOUNDS; ENANTIOSELECTIVE SYNTHESIS; COUMARIN ANTICOAGULANTS; SEPARATION; FUNCTIONALIZATION; MIL-101;

D O I：

10.1002/adsc.201300554

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A novel chiral metal-organic framework (MOF) organocatalyst has been developed, based on readily available MIL-101 and the chiral primary diamine (1R,2R)-1,2-diphenylethylenediamine, by the post-synthetic modification. Over the developed chiral heterogeneous catalyst the asymmetric synthesis of (S)-warfarin with high enantioselectivity can be fulfilled on a gram-scale (2.8g) with excellent yield (92%) at low cost, making the synthesis method an ideal alternative to existing methods.

引用

页码：2538 / 2543

页数：6

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