Conditioning of cyclophosphamide-induced leukopenia in humans

被引：0
|
作者：
Giang, DW
Goodman, AD
Schiffer, RB
Mattson, DH
Petrie, M
Cohen, N
Ader, R
机构：
[1] UNIV ROCHESTER,MED CTR,DEPT PSYCHIAT,ROCHESTER,NY 14642
[2] UNIV ROCHESTER,MED CTR,DEPT ENVIRONM MED,ROCHESTER,NY 14642
[3] UNIV ROCHESTER,MED CTR,DEPT MICROBIOL & IMMUNOL,ROCHESTER,NY 14642
[4] UNIV ROCHESTER,MED CTR,CTR PSYCHONEUROIMMUNOL RES,ROCHESTER,NY 14642
来源：
JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES | 1996年 / 8卷 / 02期
关键词：
D O I：
暂无
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
This study evaluated whether decrements in peripheral leukocyte counts induced by cyclophosphamide can be conditioned in humans. Ten subjects being treated for multiple sclerosis received four intravenous treatments with cyclophosphamide (unconditioned stimulus) paired with a conditioned stimulus. Subjects received conditioned stimulus plus 10 mg of cyclophosphamide during one of the next two treatments in a double-blind manner. Eight of 10 subjects (P = 0.044) displayed decreased peripheral leukocyte counts following conditioned stimulus. This change may have resulted from classical conditioning processes.
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页码：194 / 201
页数：8
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