Relationship between frequency of hypoglycemic episodes and changes in carotid atherosclerosis in insulin-treated patients with type 2 diabetes mellitus

被引：8

作者：

Mita, Tomoya ^{[1
]}

Katakami, Naoto ^{[2
,3
]}

Shiraiwa, Toshihiko ^{[4
]}

Yoshii, Hidenori ^{[5
]}

Kuribayashi, Nobuichi ^{[6
]}

Osonoi, Takeshi ^{[7
]}

Kaneto, Hideaki ^{[2
]}

Kosugi, Keisuke ^{[8
]}

Umayahara, Yutaka ^{[9
]}

Gosho, Masahiko ^{[10
]}

Shimomura, Iichiro ^{[2
]}

Watada, Hirotaka ^{[1
]}

机构：

[1] Juntendo Univ, Grad Sch Med, Dept Endocrinol & Metab, Bunkyo Ku, Hongo 2-1-1, Tokyo 1138421, Japan

[2] Osaka Univ, Grad Sch Med, Dept Metab Med, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan

[3] Osaka Univ, Grad Sch Med, Dept Metab & Atherosclerosis, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan

[4] Shiraiwa Med Clin, 4-10-24 Houzenji, Kashiwara, Osaka 5820005, Japan

[5] Juntendo Tokyo Koto Geriatr Med Ctr, Dept Med Diabetol & Endocrinol, Koto Ku, Shinsuna 3-3-20, Tokyo 1360075, Japan

[6] Misaki Naika Clin, 6-44-9 Futawahigashi, Funabashi, Chiba 2740805, Japan

[7] Naka Mem Clin, 745-5 Nakadai, Naka, Ibaraki 3110113, Japan

[8] Osaka Police Hosp, Tennoji Ku, 10-31 Kitayamacho, Osaka 5430035, Japan

[9] Osaka Gen Med Ctr, Sumiyoshi Ku, 3-1-56 Bandai Higashi, Osaka 5588558, Japan

[10] Univ Tsukuba, Fac Med, Dept Clin Trial & Clin Epidemiol, 1-1-1 Tennodai, Tsukuba, Ibaraki 3058575, Japan

来源：

SCIENTIFIC REPORTS | 2017年 / 7卷

关键词：

INTIMA-MEDIA THICKNESS; IMPROVES GLYCEMIC CONTROL; ADD-ON THERAPY; CARDIOVASCULAR-DISEASE; DPP-4; INHIBITOR; SITAGLIPTIN; MORTALITY; INFLAMMATION; PROGRESSION; ADRENALINE;

D O I：

10.1038/srep39965

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The effect of hypoglycemia on the progression of atherosclerosis in patients with type 2 diabetes mellitus (T2DM) remains largely unknown. This is a post hoc analysis of a randomized trial to investigate the relationship between hypoglycemic episodes and changes in carotid intima-media thickness (IMT). Among 274 study subjects, 104 patients experienced hypoglycemic episodes. Increases in the mean IMT and left maximum IMT of the common carotid arteries (CCA) were significantly greater in patients with hypoglycemia compared to those without hypoglycemia. Classification of the patients into three groups according to the frequency of hypoglycemic episodes showed that high frequency of hypoglycemic events was associated with increases in mean IMT-CCA, and left max-IMT-CCA and right max-IMT-CCA. In addition, repetitive episodes of hypoglycemia were associated with a reduction in the beneficial effects of sitagliptin on carotid IMT. Our data suggest that frequency of hypoglycemic episodes was associated with changes in carotid atherosclerosis.

引用

页数：9

共 50 条

[1] Relationship between frequency of hypoglycemic episodes and changes in carotid atherosclerosis in insulin-treated patients with type 2 diabetes mellitus
Tomoya Mita
Naoto Katakami
Toshihiko Shiraiwa
Hidenori Yoshii
Nobuichi Kuribayashi
Takeshi Osonoi
Hideaki Kaneto
Keisuke Kosugi
Yutaka Umayahara
Masahiko Gosho
Iichiro Shimomura
Hirotaka Watada
[J]. Scientific Reports, 7
[2] Relationship between serum adropin and carotid atherosclerosis in patients with type 2 diabetes mellitus
Zang, Huanhuan
Cheng, Xingbo
Jiang, Fusong
[J]. DIABETES-METABOLISM RESEARCH AND REVIEWS, 2017, 33
[3] Impaired awareness of hypoglycaemia in insulin-treated patients with type 2 diabetes mellitus
Sakane, N.
Kotani, K.
Tsuzaki, K.
Takahashi, K.
Sano, Y.
[J]. DIABETOLOGIA, 2014, 57 : S261 - S261
[4] Predictors of hypoglycemia in insulin-treated patients with type 2 diabetes mellitus in Basrah
Nassar, Dhuha Tarik
Habib, Omran S.
Mansour, Abbas Ali
[J]. WORLD JOURNAL OF DIABETES, 2016, 7 (18): : 470 - 480
[5] Relationship between anti-insulin antibodies and albuminuria or proteinuria in human insulin-treated type 2 diabetes mellitus
Katahira, M
[J]. ENDOCRINE JOURNAL, 2001, 48 (04) : 487 - 491
[6] Hypoglycaemia in insulin-treated Type 2 diabetes mellitus: frequency, symptoms and impaired awareness
Allen, KV
Henderson, JN
Deary, IJ
Frier, BM
[J]. DIABETOLOGIA, 2002, 45 : A268 - A268
[7] Optimising Therapy for Insulin-Treated Type 2 Diabetes Mellitus
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[J]. Drugs & Aging, 2000, 17 : 283 - 294
[8] Optimising therapy for insulin-treated type 2 diabetes mellitus
Hermann, LS
[J]. DRUGS & AGING, 2000, 17 (04) : 283 - 294
[9] Malignancies in patients with insulin-treated diabetes mellitus
Kath, R
Schiel, R
Müller, UA
Höffken, K
[J]. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2000, 126 (07) : 412 - 417
[10] Malignancies in patients with insulin-treated diabetes mellitus
Roland Kath
Ralf Schiel
Ulrich Alfons Müller
Klaus Höffken
[J]. Journal of Cancer Research and Clinical Oncology, 2000, 126 (7) : 412 - 417

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