In Vitro Susceptibility Testing of Bedaquiline against Mycobacterium avium Complex

被引：42

作者：

Brown-Elliott, Barbara A. ^{[1
]}

Philley, Julie V. ^{[2
]}

Griffith, David E. ^{[2
]}

Thakkar, Foram ^{[2
]}

Wallace, Richard J., Jr. ^{[1
,2
]}

机构：

[1] Univ Texas Hlth Sci Ctr Tyler, Mycobacteria Nocardia Res Lab, Dept Microbiol, Tyler, TX 75708 USA

[2] Univ Texas Hlth Sci Ctr Tyler, Dept Med, Tyler, TX USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2017年 / 61卷 / 02期

关键词：

Mycobacterium avium complex; bedaquiline; nontuberculous mycobacteria; susceptibility testing; MULTIDRUG-RESISTANT TUBERCULOSIS; ATP SYNTHASE; DIARYLQUINOLINE TMC207; CROSS-RESISTANCE; LUNG-DISEASE; DRUG; RIFAPENTINE; CLOFAZIMINE; THERAPY;

D O I：

10.1128/AAC.01798-16

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We performed bedaquiline broth microdilution susceptibility testing using Clinical and Laboratory Standards Institute (CLSI) guidelines on 103 respiratory isolates of Mycobacterium avium complex (MAC), including multidrug-resistant isolates. Approximately 90% of isolates had bedaquiline MICs of <= 0.008 mu g/ml, and 102/103 isolates had MICs of <= 0.015 mu g/ml. Bedaquiline has excellent potential for use in patients with MAC infections, although for reasons of its metabolism by the cytochrome P450 system, it should not be given with rifampin.

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页数：4

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