In Vitro Susceptibility Testing of Bedaquiline against Mycobacterium avium Complex

被引：42

作者：

Brown-Elliott, Barbara A. ^{[1
]}

Philley, Julie V. ^{[2
]}

Griffith, David E. ^{[2
]}

Thakkar, Foram ^{[2
]}

Wallace, Richard J., Jr. ^{[1
,2
]}

机构：

[1] Univ Texas Hlth Sci Ctr Tyler, Mycobacteria Nocardia Res Lab, Dept Microbiol, Tyler, TX 75708 USA

[2] Univ Texas Hlth Sci Ctr Tyler, Dept Med, Tyler, TX USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2017年 / 61卷 / 02期

关键词：

Mycobacterium avium complex; bedaquiline; nontuberculous mycobacteria; susceptibility testing; MULTIDRUG-RESISTANT TUBERCULOSIS; ATP SYNTHASE; DIARYLQUINOLINE TMC207; CROSS-RESISTANCE; LUNG-DISEASE; DRUG; RIFAPENTINE; CLOFAZIMINE; THERAPY;

D O I：

10.1128/AAC.01798-16

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We performed bedaquiline broth microdilution susceptibility testing using Clinical and Laboratory Standards Institute (CLSI) guidelines on 103 respiratory isolates of Mycobacterium avium complex (MAC), including multidrug-resistant isolates. Approximately 90% of isolates had bedaquiline MICs of <= 0.008 mu g/ml, and 102/103 isolates had MICs of <= 0.015 mu g/ml. Bedaquiline has excellent potential for use in patients with MAC infections, although for reasons of its metabolism by the cytochrome P450 system, it should not be given with rifampin.

引用

页数：4

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