Development of a yeast-based assay system for monitoring microsatellite instability

被引：0
|
作者：
Larkin, K [1 ]
Schweizer, M [1 ]
机构：
[1] Inst Food Res, Dept Genet & Microbiol, Norwich NR4 7UA, Norfolk, England
来源：
FEMS MICROBIOLOGY LETTERS | 1999年 / 176卷 / 01期
关键词：
microsatellite instability; mismatch repair; Saccharomyces cerevisiae; environmental influence;
D O I：
暂无
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Simple sequence repeats (microsatellites) are found in all eukaryotic genomes. Instabilities within these sequences have been associated with several human disorders including Huntington's chorea and myotonic dystrophy. Further studies have identified links between microsatellite instability, faulty mismatch repair and certain human cancers, in particular a form of hereditary colorectal cancer. The assay system described here consists of a congenic set of yeast strains mutated in DNA replication and mismatch repair genes and assay plasmids with which it is possible to measure differences in microsatellite stability in the range of 5-850-fold. The development of this technology will allow monitoring of environmental and dietary influences on the genomic stability in the context of human disease. (C) 1999 Published by Elsevier Science B.V. All rights reserved.
引用
收藏
页码：205 / 212
页数：8
相关论文
共 50 条
  • [1] Development of a Yeast-Based Assay for Bioavailable Phosphorus
    Shepherd, Heather A. M.
    Trentman, Matt T.
    Tank, Jennifer L.
    Praner, Jennifer
    Cervantes, Anissa
    Chaudhary, Priya
    Gezelter, Jonah
    Marrs, Allyson J.
    Myers, Kathryn A.
    Welsh, Jonathan R.
    Wu, Yueh-Fu O.
    Goodson, Holly, V
    [J]. ACS ES&T WATER, 2021, 1 (09): : 2020 - 2028
  • [2] Yeast-based assay for the measurement of positive and negative influences on microsatellite stability
    Marden, Aileen
    Walmsley, Richard M.
    Schweizer, Lilian M.
    Schweizer, Michael
    [J]. FEMS YEAST RESEARCH, 2006, 6 (05) : 716 - 725
  • [3] Development of a highthroughput yeast-based assay for detection of metabolically activated genotoxins
    Liu, Xuemei
    Kramer, Jeffrey A.
    Swaffield, Jonathan C.
    Hu, Yi
    Chai, Guixuan
    Wilson, Alan G. E.
    [J]. MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 2008, 653 (1-2) : 63 - 69
  • [4] Monitoring bisphenol A and estrogenic chemicals in thermal paper with yeast-based bioreporter assay
    Johanna Rajasärkkä
    Jani Koponen
    Riikka Airaksinen
    Hannu Kiviranta
    Marko Virta
    [J]. Analytical and Bioanalytical Chemistry, 2014, 406 : 5695 - 5702
  • [5] Monitoring bisphenol A and estrogenic chemicals in thermal paper with yeast-based bioreporter assay
    Rajasarkka, Johanna
    Koponen, Jani
    Airaksinen, Riikka
    Kiviranta, Hannu
    Virta, Marko
    [J]. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2014, 406 (23) : 5695 - 5702
  • [6] Initial prion nucleation in the yeast-based assay
    Chernoff, Yury O.
    Chandramowlishwaran, Pavithra
    Sun, Meng
    Deckner, Zachery J.
    [J]. PRION, 2013, 7 : 95 - 95
  • [7] A yeast-based cytotoxicity and genotoxicity assay for environmental monitoring using novel portable instrumentation
    Knight, AW
    Keenan, PO
    Goddard, NJ
    Fielden, PR
    Walmsley, RM
    [J]. JOURNAL OF ENVIRONMENTAL MONITORING, 2004, 6 (01): : 71 - 79
  • [8] Yeast-based Biosensors for Environmental Monitoring.
    Philip, J. T.
    Weaver, A.
    Barstis, T.
    Lieberman, M.
    Goodson, H.
    [J]. MOLECULAR BIOLOGY OF THE CELL, 2011, 22
  • [9] Yeast-based vaccines: development and application
    Breunig, Karin D.
    [J]. NEW BIOTECHNOLOGY, 2016, 33 : S58 - S58
  • [10] Development of a Yeast-Based Assay to Identify Inhibitors of PiT-1 Phosphate Transporter
    Sweeney, Joseph M.
    Akabas, Myles
    [J]. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2022, 33 (11): : 93 - 94
12345