Synthesis, antibacterial and antifungal activity of 4-substituted-5-aryl-1,2,4-triazoles

被引:158
|
作者
Colanceska-Ragenovic, K
Dimova, V
Kakurinov, V
Molnar, DG
Buzarovska, A
机构
[1] Sv Kiril & Metodij Univ, Fac Technol & Met, Skopje 1000, Macedonia
[2] Sv Kiril & Metodij Univ, Dept Microbiol, Fac Agr, Skopje 1000, Macedonia
[3] Univ Novi Sad, Fac Sci, Inst Chem, YU-21000 Novi Sad, Yugoslavia
关键词
substituted benzoyl/phenylcetyl-4-allylthiosemicarbazides; 1,2,4-triazoles; cyclization; inhibition zone;
D O I
10.3390/61000815
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A few 4-allyl/amino-5-aryl-1,2,4-triazoles were synthesized and tested for antibacterial and antifungal effects against Escherichia coli, Bacillus subtilis, Salmonella enteritidis, Staphylococcus aureus, Aspergillus niger and Candida albicans. 4-Allyl-5-aryl-1,2,4-triazoles were obtained by the oxidative cyclization of the appropriate 1-substituted-4-allylthiosemicarbazides and 4-amino-5-aryl-1,2,4-triazoles were obtained by cyclization of the potassium salts of appropriately substituted dithiocarbazinic acids with hydrazine hydrate. The new synthesized compounds were characterized using IR, H-1-NMR, C-13-NMR and UV spectral data together with elemental analysis.
引用
收藏
页码:815 / 824
页数:10
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