Associations between plasma metal mixture exposure and risk of hypertension: A cross-sectional study among adults in Shenzhen, China

被引:10
|
作者
Zheng, Sijia [1 ,2 ]
Nie, Zhiqiang [3 ]
Lv, Ziquan [2 ]
Wang, Tian [2 ,4 ]
Wei, Weizhou [5 ]
Fang, Daokui [2 ]
Zou, Xuan [2 ]
Fu, Yulin [2 ]
Cao, Tingting [2 ]
Liang, Zhaoyi [1 ,2 ]
Lu, Qi [1 ,2 ]
Huang, Hui [6 ]
Wen, Ying [2 ]
Huang, Suli [1 ,2 ]
机构
[1] Shanxi Med Univ, Sch Publ Hlth, Taiyuan, Peoples R China
[2] Shenzhen Ctr Dis Control & Prevent, Shenzhen, Peoples R China
[3] Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Guangdong Cardiovasc Inst, Dept Cardiol, Guangzhou, Peoples R China
[4] Southeast Univ, Sch Publ Hlth, Key Lab Environm Med Engn, Minist Educ, Nanjing, Peoples R China
[5] Shenzhen Yutian Community Hlth Serv Ctr, Shenzhen, Peoples R China
[6] Sun Yat sen Univ, Affiliated Hosp 8, Dept Cardiol, Shenzhen, Peoples R China
基金
中国国家自然科学基金;
关键词
hypertension; metal mixture; cobalt; aluminum; calcium; BKMR; ALUMINUM EXPOSURE; BLOOD-PRESSURE; COBALT; ELEMENTS; PREVALENCE; CALCIUM; BIOAVAILABILITY; POPULATION; AWARENESS; CADMIUM;
D O I
10.3389/fpubh.2022.1039514
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
BackgroundMetal exposure affects human health. Current studies mainly focus on the individual health effect of metal exposure on hypertension (HTN), and the results remain controversial. Moreover, the studies assessing overall effect of metal mixtures on hypertension risk are limited. MethodsA cross-sectional study was conducted by recruiting 1,546 Chinese adults who attended routine medical check-ups at the Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen. The plasma levels of 13 metals were measured using inductively coupled plasma mass spectrometry. Multivariate logistic regression model, restricted cubic spline (RCS) model and the Bayesian Kernel Machine Regression (BKMR) model were applied to explore the single and combined effect of metals on the risk of HTN. ResultsA total of 642 (41.5%) participants were diagnosed with HTN. In the logistic regression model, the adjusted odds ratios (ORs) were 0.71 (0.52, 0.97) for cobalt, 1.40 (1.04, 1.89) for calcium, 0.66 (0.48, 0.90), and 0.60 (0.43, 0.83) for aluminum in the second and third quartile, respectively. The RCS analysis showed a V-shaped or an inverse V-shaped dose-response relationship between metals (aluminum or calcium, respectively) and the risk of HTN (P for non-linearity was 0.017 or 0.009, respectively). However, no combined effect was found between metal mixture and the risk of hypertension. ConclusionsPlasma levels of cobalt, aluminum and calcium were found to be associated with the risk of HTN. Further studies are needed to confirm our findings and their potential mechanisms with prospective studies and experimental study designs.
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页数:12
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