This paper gave detailed studies on the chronology, petrology and geochemistry of the granodiorites, which are related to the mineralization in Siruyidieer Pb-Zn deposit, Taxkorgan, Xinjiang, China. Zircon LA-ICP-MS U-Pb results yield a concorde age of 12.7 +/- 0.13Ma for the granodiorites, is consistent with the existing age (11 Ma). Based on these, the Siruyidieer Pb-Zn was formed during Himalayan Period. The rocks are weak aluminum, are characterized by enrichment in aluminium and kalium, and belong to high-K calcic-alkaline-shoshonite series. In addition, the rocks have high large ion lithophile elements (LILE) (Rb, Ba, Th, U, etc.) and total rare earth element, low high field strength elements (HFSE) (Zr, Y, Ta, Nb, etc.). The granodiorites were derived from post-orogenic extensive setting. The distinctive metallogenic characteristics in study area are good record for the respond between tectonic transition zone and major collision zone in northwest of Qinghai-Tibet Plateau. Moreover, the mineralization events in this area are the result of alkali-rich magamtism and minerogenesis in different tectonic setting. The distribution of alkali-rich magama and deposits in study area are controlled by main and secondary faults.