Systems and synthetic biology of the vessel wall

被引：6

作者：

Frueh, Jennifer ^{[1
]}

Maimari, Nataly ^{[1
]}

Lui, Ying ^{[1
]}

Kis, Zoltan ^{[1
]}

Mehta, Vikram ^{[1
]}

Pormehr, Negin ^{[1
]}

Grant, Calum ^{[1
]}

Chalkias, Emmanuel ^{[1
]}

Falck-Hansen, Mika ^{[1
]}

Bovens, Sandra ^{[1
]}

Pedrigi, Ryan ^{[1
]}

Homma, Taka ^{[1
]}

Coppola, Gianfillippo ^{[1
]}

Krams, Rob ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Bioengn, Royal Sch Mines, London SW7 2AZ, England

来源：

FEBS LETTERS | 2012年 / 586卷 / 15期

关键词：

Systems medicine; Vascular; Mechanotransduction; Synthetic biology; SHEAR-STRESS; GENE-EXPRESSION; IN-VIVO; ATHEROSCLEROTIC PLAQUE; ENDOTHELIAL-CELLS; CAROTID STENOSIS; MICROARRAY DATA; DECONVOLUTION; FLOW; NETWORKS;

D O I：

10.1016/j.febslet.2012.04.031

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Atherosclerosis is intimately coupled to blood flow by the presence of predilection sites. The coupling is through mechanotransduction of endothelial cells and approximately 2000 gene are associated with this process. This paper describes a new platform to study and identify new signalling pathways in endothelial cells covering an atherosclerotic plaque. The identified networks are synthesized in primary cells to study their reaction to flow. This synthetic approach might lead to new insights and drug targets. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

页码：2164 / 2170

页数：7

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