γδ T lymphocytes in the pathogenesis of multiple sclerosis and experimental autoimmune encephalomyelitis

被引：11
|
作者：
Zarobkiewicz, Michal K. [1 ]
Kowalska, Wioleta [1 ]
Rolinski, Jacek [1 ]
Bojarska-Junak, Agnieszka A. [1 ]
机构：
[1] Med Univ Lublin, Chair & Dept Clin Immunol, Chodzki 4a, PL-20093 Lublin, Poland
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2019年 / 330卷
关键词：
Multiple sclerosis; MS; EAE; gamma delta T cells; IL-17; Experimental autoimmune encephalomyelitis; CENTRAL-NERVOUS-SYSTEM; CELL-RECEPTOR REPERTOIRE; PERIPHERAL-BLOOD; CEREBROSPINAL-FLUID; MIGRATORY PATHWAYS; IL-17; PRODUCTION; HEALTHY DONORS; IN-VITRO; EXPRESSION; CYTOTOXICITY;
D O I：
10.1016/j.jneuroim.2019.02.009
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The aim of the current review is to summarize the results of studies on the role of gamma delta T cells in the pathogenesis of multiple sclerosis and its animal model - the experimental autoimmune encephalomyelitis. Despite the fact that numerous studies have been performed, the role of gamma delta T is still not fully understood. It seems that there are two distinct subpopulations - one exacerbating the disease (IL-17-producing) and the other playing a protective role (IFN-gamma-secreting). Nevertheless, future studies are required for an understanding of gamma delta T cells role in multiple sclerosis.
引用
收藏
页码：67 / 73
页数：7
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