An overview of the vaccine adverse event reporting system (VAERS) as a surveillance system

被引：135
|
作者：
Singleton, JA
Lloyd, JC
Mootrey, GT
Salive, ME
Chen, RT
机构：
[1] Ctr Dis Control & Prevent, Natl Immunizat Program, Vaccine Safety & Dev Author, Atlanta, GA 30333 USA
[2] US FDA, Div Biostat & Epidemiol, Rockville, MD 20857 USA
来源：
VACCINE | 1999年 / 17卷 / 22期
关键词：
vaccines; postmarketing surveillance; adverse effects;
D O I：
10.1016/S0264-410X(99)00132-2
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We evaluated the Vaccine Adverse Event Reporting System (VAERS), the spontaneous reporting system for vaccine-associated adverse events in the United Slates, as a public health surveillance system, using evaluation guidelines from the Centers for Disease Control and Prevention. We found that VAERS is simple for reporters to use, flexible by design and its data are available in a timely fashion. The predictive value positive for one severe event is known to be high, but for most events is unknown. The acceptability, sensitivity and representativeness of VAERS are unknown, The study of vaccine safety is complicated by underreporting, erroneous reporting, frequent multiple exposures and multiple outcomes. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：2908 / 2917
页数：10
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