Synthesis and characterization of PLGA nanoparticles

被引:589
|
作者
Astete, Carlos E. [1 ]
Sabliov, Cristina M. [1 ]
机构
[1] Louisiana State Univ, Ctr Agr, Dept Biol & Agr Engn, Baton Rouge, LA 70803 USA
关键词
PLGA; nanoparticles; size; synthesis; characterization; emulsion evaporation;
D O I
10.1163/156856206775997322
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Poly(lactide-co-glycolide) (PLGA) nanoparticles of different physical characteristics (size, size distribution, morphology, zeta potential) can be synthesized by controlling the parameters specific to the synthesis method employed. The aim of this review is to clearly, quantitatively and comprehensively describe the top-down synthesis techniques available for PLGA nanoparticle formation. as well as the techniques commonly Used for nanoparticle characterization. Many examples are discussed in detail to provide the reader with an extensive knowledge base oil the important parameters specific to the synthesis method described and ways in which these parameters can be manipulated to control the nanoparticle physical characteristics.
引用
收藏
页码:247 / 289
页数:43
相关论文
共 50 条
  • [1] Synthesis and characterization of magnetite/PLGA/chitosan nanoparticles
    Ibarra, Jaime
    Melendres, Julio
    Almada, Mario
    Burboa, Maria G.
    Taboada, Pablo
    Juarez, Josue
    Valdez, Miguel A.
    [J]. MATERIALS RESEARCH EXPRESS, 2015, 2 (09):
  • [2] Hinokinin and Cubebin loaded PLGA and PLGA-co-PEG nanoparticles: synthesis and characterization
    de Lima, Regiane Godoy
    Barros, Maria Teresa
    Laurentiz, Rosangela da Silva
    [J]. ANNALS OF MEDICINE, 2018, 50 : S53 - S54
  • [3] Synthesis, characterization and antibacterial activity of juglone encapsulated PLGA nanoparticles
    Arasoglu, T.
    Derman, S.
    Mansuroglu, B.
    Yelkenci, G.
    Kocyigit, B.
    Gumus, B.
    Acar, T.
    Kocacaliskan, I.
    [J]. JOURNAL OF APPLIED MICROBIOLOGY, 2017, 123 (06) : 1407 - 1419
  • [4] PLGA-BISPHOSPHONATES CONJUGATED NANOPARTICLES: SYNTHESIS AND MORPHOLOGICAL CHARACTERIZATION
    Postelnicu, Roberto Angelo
    Ciocilteu, Maria Viorica
    Neacsu, Ionela Andreea
    Nicolicescu, Claudiu
    Costachi, Alexandra
    Amzoiu, Manuel
    Neamtu, Johny
    Pisoschi, Catalina Gabriela
    Mocanu, Andreea Gabriela
    Rau, Gabriela
    Amzoiu, Emilia
    [J]. FARMACIA, 2023, 71 (01) : 83 - 90
  • [5] Synthesis and characterization of PLGA nanoparticles containing mixture of curcuminoids for optimization of photodynamic inactivation
    Suzuki, Isabella L.
    Inada, Natalia M.
    Marangoni, Valeria S.
    Correa, Thaila Q.
    Zucolotto, Valtencir
    Kurachi, Cristina
    Bagnato, Vanderlei S.
    [J]. OPTICAL METHODS FOR TUMOR TREATMENT AND DETECTION: MECHANISMS AND TECHNIQUES IN PHOTODYNAMIC THERAPY XXV, 2016, 9694
  • [6] Synthesis and encapsulation of magnetite nanoparticles in PLGA: effect of amount of PLGA on characteristics of encapsulated nanoparticles
    Bootdee, Kittima
    Nithitanakul, Manit
    Grady, Brian P.
    [J]. POLYMER BULLETIN, 2012, 69 (07) : 795 - 806
  • [7] Synthesis and encapsulation of magnetite nanoparticles in PLGA: effect of amount of PLGA on characteristics of encapsulated nanoparticles
    Kittima Bootdee
    Manit Nithitanakul
    Brian P. Grady
    [J]. Polymer Bulletin, 2012, 69 : 795 - 806
  • [8] Development and characterization of PLGA nanoparticles containing antibiotics
    do Amorim Costa Gaspar, Livia Maria
    Silva Dorea, Afonso Celso
    Droppa-Almeida, Daniela
    de Melo Silva, Isabelle Souza
    Montoro, Fabiano Emmanuel
    Alves, Lumar Lucena
    Hernandez Macedo, Maria Lucila
    Padilha, Francine Ferreira
    [J]. JOURNAL OF NANOPARTICLE RESEARCH, 2018, 20 (11)
  • [9] Development and characterization of PLGA nanoparticles containing antibiotics
    Lívia Maria do Amorim Costa Gaspar
    Afonso Celso Silva Dórea
    Daniela Droppa-Almeida
    Isabelle Souza de Mélo Silva
    Fabiano Emmanuel Montoro
    Lumar Lucena Alves
    Maria Lucila Hernandez Macedo
    Francine Ferreira Padilha
    [J]. Journal of Nanoparticle Research, 2018, 20
  • [10] Synthesis and characterization of the antitubercular phenazine lapazine and development of PLGA and PCL nanoparticles for its entrapment
    Silveira, Narjara
    Longuinho, Mariana M.
    Leitao, Suzana G.
    Silva, Raphael S. F.
    Lourenco, Maria C.
    Silva, Pedro E. A.
    Pinto, Maria do Carmo F. R.
    Abracado, Leida G.
    Finotelli, Priscilla V.
    [J]. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2016, 58 : 458 - 466