Neurogenesis in a Young Dog With Epileptic Seizures

被引:2
|
作者
Borschensky, C. M. [1 ]
Woolley, J. S.
Kipar, A. [2 ]
Herden, C. [1 ]
机构
[1] Univ Giessen, Inst Vet Pathol, D-35392 Giessen, Germany
[2] Univ Liverpool, Sch Vet Sci, Liverpool L69 3BX, Merseyside, England
关键词
neurogenesis; epilepsy; brain; dog; DENTATE GYRUS; ADULT; CELLS; HIPPOCAMPUS; NEURONS;
D O I
10.1177/0300985811429308
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Epileptic seizures can lead to various reactions in the brain, ranging from neuronal necrosis and glial cell activation to focal structural disorganization. Furthermore, increased hippocampal neurogenesis has been documented in rodent models of acute convulsions. This is a report of hippocampal neurogenesis in a dog with spontaneous epileptic seizures. A 16-week-old epileptic German Shepherd Dog had marked neuronal cell proliferation (up to 5 mitotic figures per high-power field and increased immunohistochemical expression of proliferative cell nuclear antigen) in the dentate gyrus accompanied by microglial and astroglial activation. Some granule cells expressed doublecortin, a marker of immature neurons; mitotically active cells expressed neuronal nuclear antigen. No mitotic figures were found in the brain of age-matched control dogs. Whether increased neurogenesis represents a general reaction pattern of young epileptic dogs should be investigated.
引用
收藏
页码:766 / 770
页数:5
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