The Pan-PIM Kinase Inhibitor LGH447 Shows Activity In PIM2-Dependent Multiple Myeloma and In AML Models

被引：11
|
作者：
Garcia, Pablo D.
Langowski, John L.
Holash, Jocelyn
Burger, Matthew
Zang, Richard
Zavorotinskaya, Tatiana
Fanton, Christie
Saci, Abdel
Growney, Joseph
Vanasse, K. Gary
机构：
来源：
BLOOD | 2013年 / 122卷 / 21期
关键词：
D O I：
10.1182/blood.V122.21.1666.1666
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
1666
引用
收藏
页数：1
相关论文
共 32 条
  • [1] Phase 1 Study Update of the Novel Pan-Pim Kinase Inhibitor LGH447 in Patients with Relapsed/ Refractory Multiple Myeloma
    Raab, Marc S.
    Ocio, Enrique M.
    Thomas, Sheeba K.
    Guenther, Andreas
    Goh, Yeow-Tee
    Lebovic, Daniel
    Jakubowiak, Andrzej
    Song, Dongweon
    Xiang, F.
    Patel, Apurva
    Vanasse, K. Gary
    Kumar, Shaji
    [J]. BLOOD, 2014, 124 (21)
  • [2] Activity of the pan-PIM kinase inhibitor INCB053914 in models of multiple myeloma
    Koblish, Holly
    Shin, Niu
    Hall, Leslie
    Wen, Xiaoming
    O'Connor, Sybil
    Dostalik, Valerie
    Wang, Qian
    Wang, Kathy
    Covington, Maryanne
    Marando, Cindy
    Bowman, Kevin
    Boer, Jason
    Burke, Krista
    Zhang, Ke
    Feng, Hao
    Xue, Chu-Biao
    Li, Yun-Long
    Yao, Wenqing
    Huber, Reid
    Vaddi, Kris
    Scherle, Peggy
    [J]. CANCER RESEARCH, 2015, 75
  • [3] The first-in-human study of the pan-PIM kinase inhibitor PIM447 in patients with relapsed and/or refractory multiple myeloma
    Marc S. Raab
    Sheeba K. Thomas
    Enrique M. Ocio
    Andreas Guenther
    Yeow-Tee Goh
    Moshe Talpaz
    Nicolas Hohmann
    Sylvia Zhao
    Fang Xiang
    Carl Simon
    K. Gary Vanasse
    Shaji K. Kumar
    [J]. Leukemia, 2019, 33 : 2924 - 2933
  • [4] Protein Translation Inhibition is Involved in the Activity of the Pan-PIM Kinase Inhibitor PIM447 in Combination with Pomalidomide-Dexamethasone in Multiple Myeloma
    Paino, Teresa
    Gonzalez-Mendez, Lorena
    San-Segundo, Laura
    Corchete, Luis A.
    Hernandez-Garcia, Susana
    Diaz-Tejedor, Andrea
    Algarin, Esperanza M.
    Mogollon, Pedro
    Martin-Sanchez, Montserrat
    Gutierrez, Norma C.
    Mateos, Maria-Victoria
    Garayoa, Mercedes
    Ocio, Enrique M.
    [J]. CANCERS, 2020, 12 (10) : 1 - 20
  • [5] THE PAN-PIM KINASE INHIBITOR, PIM447, POTENTLY SYNERGIZES WITH POMALIDOMIDE PLUS DEXAMETHASONE IN PRECLINICAL IN VITRO AND IN VIVO MODELS OF MULTIPLE MYELOMA
    Paino, T.
    San-Segundo, L.
    Hernandez-Garcia, S.
    Gonzalez-Mendez, L.
    Algarin, E. M.
    Martin-Sanchez, M.
    Mateos, M. -V.
    Garayoa, M.
    Ocio, E. M.
    [J]. HAEMATOLOGICA, 2017, 102 : 501 - 501
  • [6] The first-in-human study of the pan-PIM kinase inhibitor PIM447 in patients with relapsed and/or refractory multiple myeloma
    Raab, Marc S.
    Thomas, Sheeba K.
    Ocio, Enrique M.
    Guenther, Andreas
    Goh, Yeow-Tee
    Talpaz, Moshe
    Hohmann, Nicolas
    Zhao, Sylvia
    Xiang, Fang
    Simon, Carl
    Vanasse, K. Gary
    Kumar, Shaji K.
    [J]. LEUKEMIA, 2019, 33 (12) : 2924 - 2933
  • [7] The pan-PIM inhibitor PIM447 enhances the antitumor activity of lenalidomide in multiple myeloma cells via synergistic inhibition of c-MYC
    Hao, Huaixiang
    Wang, Dannie
    Vanasse, Gary
    Caponigro, Giordano
    [J]. CANCER RESEARCH, 2016, 76
  • [8] THE COMBINATION OF JAK INHIBITOR RUXOLITINIB, PAN-PIM INHIBITOR LGH447, AND CDK4/6 INHIBITOR LEE011 IN A PRECLINICAL MOUSE MODEL OF MYELOPROLIFERATIVE NEOPLASIA
    Pinzon-Ortiz, M.
    Rong, X.
    Saci, A.
    Vanasse, G.
    Schlegel, R.
    Caponigro, G.
    Cao, Z. A.
    [J]. HAEMATOLOGICA, 2014, 99 : 252 - 252
  • [9] The combination of JAK inhibitor, ruxolitinib, pan-PIM inhibitor, LGH447, and CDK4/6 inhibitor, LEE011, in a preclinical mouse model of myeloproliferative neoplasia
    Pinzon-Ortiz, Maria
    Rong, Xianhui
    Saci, Abdel
    Schlegel, Robert
    Vanasse, Gary
    Caponigro, Giordano
    Cao, Z. Alexander
    [J]. CANCER RESEARCH, 2014, 74 (19)
  • [10] Prognostic Implications of PIM-2 Expression in Samples from Patients with Chronic Lymphocytic Leukemia and Impact in the Sensitivity to the Pan-PIM Kinase Inhibitor PIM447
    Alicia Lopez-Iglesias, Ana
    Misiewicz-Krzeminska, Irena
    Criado, Ignacio
    Alcoceba, Miguel
    Hernandez-Garcia, Susana
    San-Segundo, Laura
    Gonzalez-Mendez, Lorena
    Martin-Sanchez, Montserrat
    Algarin, Esperanza M.
    Paino, Teresa
    Garayoa, Mercedes
    Gutierrez, Norma C.
    Mateos, Maria-Victoria
    Gonzalez-Diaz, Marcos
    Ocio, Enrique M.
    [J]. BLOOD, 2015, 126 (23)
1234