Iota-Carrageenan Prevents the Replication of SARS-CoV-2 in a Human Respiratory Epithelium Cell Line in vitro

被引：7
|
作者：
Varese, Augusto [1 ,2 ]
Paletta, Ana [1 ,2 ]
Ceballos, Ana [1 ,2 ]
Palacios, Carlos Adolfo [3 ]
Figueroa, Juan Manuel [3 ]
Dugour, Andrea Vanesa [3 ]
机构：
[1] Univ Buenos Aires, Inst Invest Biomed Retrovirus, CONICET, Buenos Aires, Argentina
[2] Univ Buenos Aires UBA, SIDA INBIRS, CONICET, Buenos Aires, Argentina
[3] Consejo Nacl Invest Cient & Tecn CONICET, Resp Res Grp, Fdn Pablo Cassara, Inst Ciencia & Tecnol Dr Cesar Milstein, Buenos Aires, Argentina
来源：
FRONTIERS IN VIROLOGY | 2021年 / 1卷
关键词：
SARS-CoV-2; COVID-19; iota-carrageenan; respiratory epithelium; antivirals; RAPID DEVELOPMENT; INTRANASAL DRUG; NASAL; POLYSACCHARIDES; DELIVERY; PROTEIN;
D O I：
10.3389/fviro.2021.746824
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Iota-carrageenan is a sulfated polysaccharide extracted from red seaweeds, which, formulated into a nasal spray, has already been proven safe and effective in viral upper respiratory infections. In Calu-3, a human respiratory epithelium cell line, we explored the activity of a formula of iota-carrageenan and sodium chloride against SARS-CoV-2. In this study, the assayed formula, already approved as a nasal spray for human use, effectively inhibited SARS-CoV-2 infection, providing a more substantial reference for clinical studies or developments.
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页数：7
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