α-Fetoprotein-producing gastric carcinoma and combined hepatocellular and cholangiocarcinoma show similar morphology but different histogenesis with respect to SALL4 expression

被引：47

作者：

Ikeda, Hiroko ^{[1
]}

Sato, Yasunori ^{[2
]}

Yoneda, Norihide ^{[3
]}

Harada, Kenichi ^{[2
]}

Sasaki, Motoko ^{[2
]}

Kitamura, Seiko ^{[1
]}

Sudo, Yoshiko ^{[4
]}

Ooi, Akishi

Nakanuma, Yasuni ^{[2
]}

机构：

[1] Kanazawa Univ Hosp, Sect Diagnost Pathol, Kanazawa, Ishikawa 9208641, Japan

[2] Kanazawa Univ, Grad Sch Med, Dept Human Pathol, Kanazawa, Ishikawa 9208641, Japan

[3] Kanazawa Univ Hosp, Kanazawa, Ishikawa 9208641, Japan

[4] Fukui Saiseikai Hosp, Dept Pathol, Fukui 9188503, Japan

来源：

HUMAN PATHOLOGY | 2012年 / 43卷 / 11期

关键词：

AFP-producing gastric cancer; Combined hepatocellular-cholangiocarcinoma; Fetal liver; SALL4; Stem cells; HEPATIC STEM/PROGENITOR CELLS; SELF-RENEWAL; CLEAR-CELL; YOLK-SAC; LIVER; CANCER; FEATURES; MARKER; TUMORS;

D O I：

10.1016/j.humpath.2011.11.022

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

alpha-Fetoprotein is expressed in hepatocellular carcinoma, yolk sac tumor, and some gastric carcinomas. The alpha-fetoprotein-producing gastric carcinoma composed of hepatoid and common adenocarcinoma shows morphological similarities to combined hepatocellular and cholangiocarcinoma. In this study, the expression of putative hepatic stem/progenitor markers (EpCAM, OV-6, DLK-1, and NCAM/CD56), hepatocyte markers (HepPar1, alpha-fetoprotein, glypican 3), and the germ cell marker SALL4 was examined in alpha-fetoprotein-producing gastric carcinoma (20 cases) and combined hepatocellular and cholangiocarcinoma (20 cases) for evaluation of pathologic differentiation and also the histogenesis of both tumors. The SALL4 protein was expressed in 95% of alpha-fetoprotein-producing gastric carcinoma, including the hepatoid component (hepatoid gastric carcinoma), but was absent in combined hepatocellular and cholangiocarcinoma. Glypican 3 and alpha-fetoprotein were detected in all hepatoid-type alpha-fetoprotein-producing gastric carcinoma but variably in combined hepatocellular and cholangiocarcinoma. NCAM/CD56 was expressed focally in combined hepatocellular and cholangiocarcinoma but was rare in hepatoid gastric carcinoma. EpCAM, DLK-1, and OV6 were variably expressed in hepatoid gastric carcinoma and combined hepatocellular and cholangiocarcinoma. SALL4 was a useful differential marker for combined hepatocellular and cholangiocarcinoma and hepatoid gastric carcinoma. The histogenesis of hepatoid gastric carcinoma expressing SALL4 seems to reflect fetal gut differentiation or involve the germ cell lineage and may be different from that of combined hepatocellular and cholangiocarcinoma involving the hepatic stem cell or progenitor cell lineages. In conclusion, hepatoid gastric carcinoma and combined hepatocellular and cholangiocarcinoma shared morphologies, whereas the distinction of hepatoid gastric carcinoma from combined hepatocellular and cholangiocarcinoma is possible by immunostaining for SALL4. These 2 tumors seem to differ in their histogenesis with respect to SALL4 expression. I. (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：1955 / 1963

页数：9

共 1 条

[1] Expression of RNA-binding protein LIN28 in classic gastric hepatoid carcinomas, gastric fetal type gastrointestinal adenocarcinomas, and hepatocellular carcinomas: An immunohistochemical study with comparison to SALL4, alpha-fetoprotein, glypican-3, and Hep Par1
Zhao, Ming
Sun, Lu
Lai, Jenny Z.
Shi, Huaiyin
Mei, Kaiyong
He, Xianglei
Jin, Xiaolong
Lai, Jinping
Cao, Dengfeng
PATHOLOGY RESEARCH AND PRACTICE, 2018, 214 (10) : 1707 - 1712

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