Gold nanoparticles increases UV and thermal stability of human serum albumin

被引：22

作者：

Capomaccio, Robin ^{[1
,2
]}

Osorio, Ines ^{[1
]}

Ojea-Jimenez, Isaac ^{[1
]}

Ceccone, Giacomo ^{[1
]}

Colpo, Pascal ^{[1
]}

Gilliland, Douglas ^{[1
]}

Hussain, Rohanah ^{[3
]}

Siligardi, Giuliano ^{[3
]}

Rossi, Francois ^{[1
]}

Ricard-Blum, Sylvie ^{[2
]}

Calzolai, Luigi ^{[1
]}

机构：

[1] European Commiss, DG Joint Res Ctr, Via E Fermi 2749, I-21027 Ispra, VA, Italy

[2] Univ Claude Bernard Lyon 1, Univ Lyon 1, ICBMS, CNRS,UMR 5246, 43 Blvd 11 Novembre 1918, F-69622 Villeurbanne, France

[3] Diamond Light Source, Didcot OX11 0DE, Oxon, England

来源：

BIOINTERPHASES | 2016年 / 11卷 / 04期

关键词：

CIRCULAR-DICHROISM; BEAMLINE B23; BINDING;

D O I：

10.1116/1.4972113

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Ultraviolet (UV) radiation, temperature, and time can degrade proteins. Here, the authors show that gold nanoparticles significantly protect human serum albumin from denaturation when exposed to "stressing" conditions such as UV irradiation and sustained exposure in suboptimal conditions. In particular, the authors show that gold nanoparticles significantly reduce the decrease in secondary structure induced by UV irradiation or extended exposure to ambient temperature. (C) 2016 Author(s).

引用

页数：5

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