Antidotal efficacy of quinuclidinium oximes against soman poisoning

被引:18
|
作者
Lucic, A
Radic, B
Peraica, M
Mesic, M
Primozic, I
Binenfeld, Z
机构
[1] INST MED ISTRAZIVANJA & MED RADA, LAB TOKSIKOL, ZAGREB 1000, CROATIA
[2] UNIV ZAGREB, SVEUCILISTE ZAGREBU, PRIRODOSLOVNO MATEMAT FAK, LAB ORGAN KEM, ZAGREB 1000, CROATIA
关键词
acetylcholinesterase reactivators; oximes; quinuclidinium compounds; soman;
D O I
10.1007/s002040050413
中图分类号
R99 [毒物学(毒理学)];
学科分类号
100405 ;
摘要
The efficiency of newly synthesized oxime derivatives of quinuclidinium were tested in vitro on soman inhibited acetylcholinesterase (AChE) of human erythrocytes and in vivo using soman poisoned mice. For this purpose, the inhibitory power of oximes (IC50), acute toxicity (LD50) as well as reactivating and protective capacities with respect to soman-inhibited AChE were determined for each of the oximes. All oximes tested were ineffective in vitro but protected mice very efficiently (BM-1 protects against 4LD(50) of soman). The results indicate that the in vivo effectiveness of quinuclidinium oximes against soman poisoning may not be related to reactivation or protection of AChE but rather to some other mechanism of the cholinergic system.
引用
收藏
页码:467 / 470
页数:4
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