Isolation of novel stilbenoids from the roots of Cyrtopodium paniculatum (Orchidaceae)

被引：11

作者：

Auberon, Florence ^{[1
]}

Olatunji, Opeyemi Joshua ^{[1
]}

Raminoson, Diamondra ^{[1
]}

Muller, Christian D. ^{[2
]}

Soengas, Beatriz ^{[3
]}

Bonte, Frederic ^{[3
]}

Lobstein, Annelise ^{[1
]}

机构：

[1] Strasbourg Univ, Lab Pharmacognosy & Bioact Nat Prod, Fac Pharm, F-67400 Illkirch Graffenstaden, France

[2] Strasbourg Univ, Inst Pluridisciplinaire Hubert Curien, UMR CNRS 7178, F-67401 Illkirch Graffenstaden, France

[3] LVMH Rech, F-45800 St Jean De Braye, France

来源：

FITOTERAPIA | 2017年 / 116卷

关键词：

Cyrtopodium paniculatum; Orchidaceae; Stilbenoids; Phenanthrenes; Phenanthrene dimers; Human glioblastoma; PHENANTHRENE DERIVATIVES; DIMERIC PHENANTHRENES; CHEMICAL-CONSTITUENTS; ANTIFUNGAL ACTIVITY; ERIA-CARINATA; 9,10-DIHYDROPHENANTHRENE; BIPHENANTHRENES; BIBENZYLS; DIHYDROPHENANTHRENES; LOROGLOSSOL;

D O I：

10.1016/j.fitote.2016.11.015

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Four new stilbenoids, named cyrtopodinone (1), cyrtopodinol (2), and coeludols A and B (3-4) were isolated from the roots of Cyrtopodium paniculatum, together with 21 known stilbenoids derivatives (5-25). Their structures were elucidated by comprehensive spectroscopic analysis including extensive 1D and 2D-NMR techniques. The cytotoxic activities of the isolated compounds were tested on human glioblastoma U-87MG cell line with fluorescence-based image cytometry. Only four compounds (18, 19, 22 and 25) displayed moderate cytotoxicity with IC50 values of 45.2, 39.9, 58.2 and 48.0 mu M, respectively. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：99 / 105

页数：7

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