TOTAL SYNTHESIS OF HAPLACUTINES B AND C

被引：0
|
作者：
Kutsumura, Noriki [1 ,2 ]
Numata, Keisuke [2 ]
Mosaki, Shiho [2 ]
Saito, Takao [2 ]
机构：
[1] Univ Tsukuba, Int Inst Integrat Sleep Med WPI IIIS, 1-1-1 Tennodai, Tsukuba, Ibaraki 3058575, Japan
[2] Tokyo Univ Sci, Fac Sci, Dept Chem, Shinjuku Ku, Tokyo 1628601, Japan
来源：
HETEROCYCLES | 2019年 / 99卷 / 01期
关键词：
DBU CONDITIONS; CYCLIZATION;
D O I：
10.3987/COM-18-S(F)7
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The total synthesis of 4-quinolone alkaloids, haplacutines B and C, has been achieved. The synthetic highlights are chemoselective construction of a 2-alkyl-4-quinolone skeleton via intramolecular base-promoted cyclocondensation of ortho-alkylamidoacetophenone and stereoselective elongation of the dienol side chain via the Stille coupling.
引用
收藏
页码：614 / 624
页数：11
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