Lymphocytes in sural nerve biopsies from patients with plasma cell dyscrasia and polyneuropathy

被引:0
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作者
Solders, G [1 ]
Nennesmo, I
Ernerudh, J
Cruz, M
Vrethem, M
机构
[1] Huddinge Hosp, Dept Neurol, S-14186 Huddinge, Sweden
[2] Huddinge Hosp, Dept Clin Neurophysiol, S-14186 Huddinge, Sweden
[3] Huddinge Hosp, Dept Pathol, S-14186 Huddinge, Sweden
[4] Linkoping Univ Hosp, Dept Neurol, S-58185 Linkoping, Sweden
[5] Linkoping Univ Hosp, Dept Clin Neurophysiol, S-58185 Linkoping, Sweden
[6] Linkoping Univ Hosp, Dept Transfus Med & Clin Immunol, S-58185 Linkoping, Sweden
关键词
MGUS; polyneuropathies; plasma cell dyscrasia; nerve biopsy; lymphocytes;
D O I
暂无
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Sural nerve biopsies were examined in 36 patients with plasmacell dyscrasia and polyneuropathy. The M-component isotype was IgM in 19, IgG in 16 (one patient had both IgM and IgG) and IgA in 2 patients. Five of the IgM patients had Waldenstrom's disease, one of the IgG cases a myeloma and two lymphoma. The remaining 28 patients had monoclonal gammopathy of uncertain significance (MGUS). Nerve conduction studies showed signs of mixed axonal/demyelinating polyneuropathy in most cases. The biopsies were evaluated with regard to nerve fibre loss, segmental demyelination and inflammatory cell infiltration. Inflammatory cells infiltrating the nerves were found in 7 of 19 IgM cases and in 6 of 16 IgG cases. Immunohistochemical staining with monoclonal antibodies to B-lymphocytes and to subsets of T-lymphocytes was performed in 33 cases. An equal distribution of CD4 and CD8 positive T cells, but no B cells, were found among the inflammatory cells. The findings indicate a possible role for cell mediated immunological mechanisms in some patients with plasma cell dyscrasia associated with polyneuropathy.
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页码:91 / 98
页数:8
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