Selective Reduction of Carboxylic Acids to Aldehydes Catalyzed by B(C6F5)3

被引：83

作者：

Bezier, David ^{[1
]}

Park, Sehoon ^{[1
]}

Brookhart, Maurice ^{[1
]}

机构：

[1] Univ N Carolina, Dept Chem, Chapel Hill, NC 27599 USA

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 03期

基金：

美国国家科学基金会;

关键词：

ONE-POT CONVERSION; CHEMOSELECTIVE CONVERSION; ORGANIC-COMPOUNDS; METHYL SULFIDE; HYDROGENATION; CHLORIDE; HYDRIDE; KETONES; HYDROSILATION;

D O I：

10.1021/ol303296a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

B(C6F5)(3) efficiently catalyzes hydrosilylation of aliphatic and aromatic carboxylic acids to produce disilyl acetals under mild conditions. Catalyst loadings can be as low as 0.05 mol %, and bulky tertiary silanes are favored to give selectively the acetals. Acidic workup of the disilyl acetals results in the formation of aldehydes in good to excellent yields.

引用

页码：496 / 499

页数：4

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