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The development of nonpeptide angiotensin II receptor antagonists: A success story

被引：0
|
作者：
Holtje, HD
Jessen, G
Holtje, M
机构：
[1] FORSCHUNGSZENTRUM JULICH, FORSCHUNGSZENTRUM, JULICH, GERMANY
[2] UNIV DUSSELDORF, INST PHARMACEUT CHEM, D-40225 DUSSELDORF, GERMANY
来源：
PHARMAZIE | 1997年 / 52卷 / 02期
关键词：
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The modulation of the renin-angiotensin system continues to be an important target in drug design. The development of nonpeptide angiotensin II receptor antagonists offers a new tool in treatment of hypertension. Starting from benzimidazole lead structures detailed structure-activity analyses, molecular modeling methods, and dedicated syntheses led to the development of potent, orally active antihypertensive drugs.
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页码：83 / 86
页数：4
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